... protein C (APC) was greater than that by heparin. In this study, we compared the bleeding complication of intravenously administered APC and heparin in rabbits, and also estimated primary hemostasis. When both anticoagulants were intravenously infused, the bleeding time from a punctured ear vein...

...J.F. Schenk; E. Glusa; P. Radziwon; A. Butti; F. Markwardt; H.K. Breddin The pharmacodynamic effects of different intravenous and subcutaneous doses of a recombinant hirudin (r-hirudin; IK-HIR02) on clotting parameters and bleeding time were investigated in 24 healthy volunteers in a bicenter study...

... or thrombin-induced platelet aggregation in vitro. In the rat wire coil-induced thrombosis model, a 50% thrombo-protective effect may be brought about with doses of 0.043 μmol/kg of rhirudin and 1.43 μmol/kg of the synthetic peptide. However, doubling of bleeding times is caused, on average, by dosages...

... Thrombocytopenia Bone marrow transplantation Bleeding time Thrombostat Platelet aggregometer 14 07 1996 9 12 1996 28 4 2009 ll;rm osl;isis M.A.A. Kratzer3 K. Storcka J. Grohh Institute für Klinische Chemie und Anästhesiologie, Klinikum Grosshadem, Universität München, Deutschland...

... of the heart, kidneys, or lungs. Furthermore, bleeding time prolongation induced by bolus application of 3.0 and 30.0 mg/kg r-hirudin was significantly inhibited by APC within 5 min. These results suggest that administration of APC may be an effective way to reverse the effects of r-hirudin in the coagulation...

...-161 Plasma TFPI Bleeding time Haemostasis 1993;23(suppl 1): 112 117 Jan Holsta Beugt Lindblada David BergqvisU Oie Nordfangb Per B. 0stergaardh Jens L. Petersenb Gert Nielsenb Ulla Hednerb a Department of Surgery and Experimental Research, Malmö General Hospital, University of Lund, Malmö...

... reported to occur within the bleeding time wound and infusion of recombinant FVIIa (rFIIa) has been shown to shorten the bleeding time in rabbits. We have investigated whether infusion of rFVIIa would enhance fibrin formation in bleeding time wounds in patients with thrombocytopenia as reflected...

...C. Ruan; G. Destelle; Z. Wang; H. Wan; Y. He; D. Cheng; P. Li; M. Duffas The compared inhibitory effects of two dose levels of ticlopidine (250 and 500 mg/day) on bleeding time and platelet function in Chinese volunteers have been studied in a placebo-controlled study. Ticlopidine exerted several...

...C. Doutremepuich; O. de Sèze; D. Le Roy; M.C. Lalanne; M.C. Anne Aspirin at very ultra low dosage was tested in healthy volunteers (n = 20) in a randomized, double-blind and placebo-controlled trial. The results showed a bleeding time reduction (p < 0.05) in volunteers having previously ingested...

... healthy volunteers received these drugs on 2 separate days, 2 weeks apart. While ASA significantly prolonged bleeding time, and decreased plasma thromboxane generation and serum thromboxane B 2 levels, CMT failed to produce such effects. Thus CMT, which lacks an acetyl moiety in its structure, has...

...A.O. Oyekan; A.O. Onabanjo The possible involvement of platelets in the pathogenesis of malaria was examined by monitoring the changes in platelet function (bleeding time [BT] and thrombin time [TT]) concomitantly with changes in packed cell volume (PCV) and erythrocyte infection rate (EIR...

...Melitta Just; Dominique Tripier; Dirk Seiffge The effect of recombinant hirudin (r-hirudin; HBW 023) was studied in four different models of thrombosis as well as on bleeding time. Arteriolar thrombus formation was induced in rats either by argon laser injury or by photochemical reaction. r-Hirudin...

... Medicine, University Hospital, Justus Liebig University, Giessen, FRG Key Words. Unfractionated heparin Low-molecular-weight heparin Platelet function Platelet count Bleeding time Spontaneous platelet aggregation ADP-induced platelet aggregation ADP-induced fibrinogen binding to platelets...

...M. Small; G.D.O. Lowe; E. Cameron; C.D. Forbes Bleeding time, platelet count and haematocrit were performed in 64 normal, anaemic and polycythaemic subjects with normal renal function and platelet counts over 100 B× 10 9 /l. There was a significant inverse correlation between the bleeding time...

..., but LMWH at the low dosages tested (0.1 and 0.25 mg/kg) demonstrated significantly higher activity than H. In a rat bleeding time test (transection model) both heparins produced a prolonged bleeding time, but LMWH possessed significantly less potency than H at all the dosages tested. Ex vivo coagulation...

...Margareta Thorngren; Shahida Shafi; G.V.R. Born The Simplate II technique for measuring bleeding time was adapted to quantify the volume of blood as a function of time and for determining how this parameter was affected by either acetylsalicylic acid (ASA) or a dietary supplement offish. Both...

..., on the third and seventh day of treatment with the drug or the placebo. Bleeding time was significantly lengthened by ticlopidine administration. Platelet aggregation, both in vivo and in vitro, was significantly inhibited during the week on ticlopidine. Beta-thromboglobulin concentration was on an average...

.... The platelet isolation and labelling procedures exerted no certain influence on the aggregation response, and platelet surface/volume calculations did not indicate that platelet activation had taken place. Bleeding time experiments in rabbits indicated that the hemostatic effectiveness of the labelled...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Coagulation Bleeding time Blood sampling Rats Haemostasis 3 : 296-305 (1974) Sampling...

... as the mobility of F. VIII R: AG in crossed immunoelectrophoresis and the alterations of bleeding time were continuously monitored. DDAVP induced both quantitative and qualitative changes of F. VIII-related properties. The bleeding time was markedly reduced for some hours. The therapy was well tolerated...