...J.W.M. Krulder; A.F. Strebus; A.E. Meinders; E. Briët The aim of the study was to determine the effect of the antithrombin concentration on the anticoagulant response to heparin in vitro. Pooled plasma was depleted of antithrombin using heparin Sepharose. Unfractionated heparin (final concentration...

... tissue factor and IL-6 release by mononuclear cells (MNC), but enhanced IL-1β-evoked tissue factor activity. Clinical antithrombin (AT) concentrates inhibited, in a dose-dependent manner, tissue factor and IL-6 production by MNC and human umbilical vein endothelial cells (HUVEC). The three...

... bound in rabbits for at least 24 h and is able to enhance the inactivation process of thrombin and factor Xa. Heparin subcutaneously (200 U/kg) injected for 2 weeks resulted in an enhanced inactivation of thrombin and factor Xa by the endothelium. The antithrombin-enhancing activity persists longer than...

... as well as a number of protective functions. The activities of thrombin and other serine proteases are modulated by the serine potease inhibitors (serpins), including antithrombin III and heparin cofactor II which are important in regulating the physiological anticoagulant action of glycosaminoglycans...

..., for heparan sulfate. One such structure is the antithrombin-binding region which is comprised by a specific pentasaccharide sequence with a 3-O-sulfated GlcN marker group. Aspects of regulation of polymer modification are discussed. Haemostasis 1990;20(suppl 1): 146-153 © 1990 S. Karger AG, Basel 0301-014 7...

... assess the extents to which LMW heparins have suppressed in vivo coagulation may provide more reliable markers for their antithrombotic effectiveness or lack thereof. Heparin Low molecular weight heparin Anti-factor Xa Antithrombin © 1990 S. Karger AG, Basel 1990 Copyright / Drug Dosage...

...S. Schulman; H. Johnsson; B. Wiman In order to assess thrombogenicity and liver toxicity of different coagulation factor concentrates, antithrombin III, soluble fibrin, alanine aminotransferase (ALAT) and gamma-glutamyl transpeptidase (GT) were measured in samples taken before, 30 min and 24 h...

...Anne Karin Lindahl; Per Morten Sandset; Ulrich Abildgaard The mean levels of fibrinopeptide A (FPA), thrombin-antithrombin complex (TAT), and soluble fibrin (tPA method) in cancer patients (n = 32) were intermediate between those of patients with cerebral infarction and pancreatitis who had...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Factor IX Factor VIII Factor X Antithrombin Feedback control Mathematical models Haemostasis 1991;21:208-218 © 1991 S. Karger AG, Basel 0301-0147/91 /0214-0208S2.75/0...

...%, respectively, of control values in nonheparinized blood. When monospecific, neutralizing IgG against extrinsic pathway inhibitor (anti-EPI) were added to heparinized blood prior to TP, the amount of FPA increased to 65%. When monospecific IgG blocking antithrombin (anti-AT) was used, the amount of FPA...

... to show that the effect of heparin on platelets is antibody- and antithrombin-III-independent. LMW heparin fractions in general exhibit a reduced platelet activating activity although there are differences between the LMW heparin fractions available. The stimulating effect of LMW heparin on platelets...

... Antithrombotic Anticoagulant Antithrombin Abstract. The anticoagulant and antithrombotic effect of heparin has been known for many decades. Nevertheless, the knowledge of structure-activity relationships and its mechanisms of action has been rather limited. However, in recent years important progress has been...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Electric Enzyme Determination Antithrombin Whole blood Haemostasis 7: 135-136 (1978) New Electric Method...

...-Phe-Val-Arg- p -nitroanilide (S 2160). After thrombin addition to plasma, only about 1.7 % of the added thrombin activity was recovered in the α 2 -macroglobulin precipitate. It is suggested that the contribution of α 2 -macroglobulin to the antithrombin activity of normal plasma is of little...

... approximately one-third to the anticoagulant effect of heparin, the remaining being accounted for by antithrombin. Released TFPI, but not plasma TFPI, contains the basic carboxy-terminal tail which is important for the anticoagulant effect. UFH and LMWH exert differential effects on intravascular TFPI. UFH...

...Tomas Velan; Wayne L. Chandler The in vivo concentration of active thrombin and the second-order rate constant for the inhibition of thrombin by antithrombin (k inh ) were estimated in patients undergoing cardiopulmonary bypass (CPB) based on measured levels of hemostatic markers in combination...

...Jawed Fareed; Debra Hoppensteadt; Omer Iqbal; Mehmut Tobu; Bruce E. Lewis Argatroban was the very first antithrombin agent that was approved for clinical use. It represents a synthetic arginomimetic drug with multiple pharmacologic properties. Unlike other antithrombin drugs, argatroban...

...Jürgen Römisch; Reiner Dönges; Harald Stauss; Dietrich Inthorn; Dieter Mühlbayer; Marianne Jochum; Johannes N. Hoffmann Antithrombin (AT) circulates in plasma in two isoforms, AT-α (90–95%) and AT-β (5–10%). AT isoform proportions were measured in plasma samples of 17 healthy subjects and 26...