... for 6 consecutive days. Mental stress induced in patients significant increments in different hemodynamic parameters (heart rate, systolic blood pressure and diastolic blood pressure) and in serum epinephrine levels. Concomitantly, the test produced a significant increase in platelet aggregation...

... change after extracorporeal bypass. Twenty-two patients undergoing cardiopulmonary bypass (CPB) were studied prior to anesthesia and immediately after the operation. Platelets activated by different agonists were monitored simultaneously for morphological changes, ATP release and aggregation. While shape...

... epinephrine-induced aggregation at the micromolar level. At higher doses (approximately 1 m M ), a weak inhibition of ADP- and collagen-induced aggregation was observed; at these concentrations, buflomedil inhibits granular secretion and the interaction of fibrinogen with its receptor on platelet. Further...

... (AA). Aggregations induced by ADP were totally suppressed upon drug administration. AA-induced aggregations were partly but significantly inhibited (p < 0.05). Responses of platelets to PAF-acether before treatment differed from patient to patient. A paired Student’s test and a two-way analysis...

...E. Glusa Recombinant hirudin (r-hirudin) inhibited the thrombin-induced aggregation and 14 C-serotonin secretion of human platelets in the same concentration range as native hirudin. In r-hirudinized blood, lower spontaneous platelet aggregation was found than in citrated or heparinized blood...

...C.M. Kirchmaier; O.K. Bellinger; B. Schulz; H.K. Breddin Cytosolic Ca 2+ concentration, [Ca 2+ ] i , and aggregation behavior of hirudinized platelet suspensions were examined under stimulation with thrombin, adinosine diphosphate, platelet-activating factor, collagen and the calcium ionophore...

...Erika Glusa; Fritz Markwardt The influence of genetically engineered recombinant hirudin (r-hirudin) on platelet functions was studied. Depending on the concentration, r-hirudin inhibits the thrombin-induced aggregation and 14 C-serotonin secretion to the same extent as native hirudin. Comparative...

...M. McClure; G.D. Duncan; G.V.R. Born; F. Robicsek Microscopic particles of microfibrillar collagen hemostat (MCH) have been shown to pass through a 40-μm blood transfusion filter. This study indicates that MCH passing through the filter retains a significant portion of its ability to aggregate...

...K.S. Herrmann; F. Seuter Different, tissue-dependent antiaggregatory properties of endothelial cells are suggested by in vitro findings, which show different spectra and amounts of arachidonic acid products to be synthesized by vessels of different type and origin. Platelet aggregation was assessed...

... of platelets with insolubilised IgG obtained from the anti-platelet membrane serum indicated a greater reaction between the antiserum and the platelet surface. Fab fragments from the antiserum inhibited ristocetin-induced aggregation of platelets and partially inhibited collagen-induced aggregation but did...

...Kai Gjerløff Schmidt; Jens Wæver Rasmussen; Martin Lorentzen 111 In-labelled human platelets were aggregated with ADP and subjected to ultra-structural morphometric analysis. In addition, the hemostatic function in vivo and the ultra-structural morphology ex vivo of rabbit platelets were examined...

... into the test medium of pH 7.4, the washed platelets aggregate with low concentrations of ADP or epinephrine in the presence of fibrinogen and Ca 2+ . The morphological and functional quality of platelet concentrates (6 × 10 6 μl -1 ) stored in acid citrate pH 6.5 is maintained for at least 6 h at room...

...Liberto Pechet; Cheryl Y. Tiarks; Barbara A. Esposito Trypsin was studied as an aggregating and release-inducing agent with gel-filtered platelets (GFP) and was compared with ADP, epinephrine and collagen. GFP aggregated irreversibly with final concentrations of 0.5–4 μ g/ml trypsin, 1.6–3.2 μM ADP...

...Leon Imandt; Dorien Tyhuis; Hans Wessels; Clemens Haanen In citrated platelet-rich plasma of eight mammalian species lithium produces species-dependent effects on ADP aggregation ranging from stimulation to inhibition. Raising the extracellular calcium concentration enhanced aggregation of both...

...Elena Tremoli; Paola Maderna; Marina Sirtori; Cesare R. Sirtori Platelet aggregation induced by threshold concentrations of ADP, adrenaline, collagen and Thrombofax® was evaluated in 25 type IIA hypercholesterolemic patients in comparison with 15 control subjects. Malondialdehyde (MDA) formation...

...A.T. Nurden; P.D. Butcher; R. Bredoux; J.P. Caen Trypsin, which induced a rapid shape change followed by a large irreversible aggregation in gel-filtered control human platelets, induced an apparently normal shape change but no aggregation in gel-filtered thrombasthenic platelets. Addition...

...Anne-Carine Østvold; May Elisabeth Lindberg; Nils Olav Solum; Holm Holmsen Human platelets, prelabelled with [ 3 H]-adenine in vitro , were aggregated biphasically by bovine fibrinogen/factor VIII, and the amounts and specific radioactivity of ADP and ATP as well as the radioactivity of ATP, ADP...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Platelets Aggregation Release Thrombin Heparin Hirudin β...

...J.M. Iacono; R.A. Binder; M.W. Marshall; N.W. Schoene; J.A. Jencks; J.F. Mackin A study was conducted in seven males and eight females to determine the effect of feeding 25 and 35% fat calories on plasma lipids, blood clotting parameters and platelet aggregation. A statistically significant...

...K.D. Butler; R.B. Wallis; A.M. White In guinea pigs, sodium arachidonate-induced platelet aggregation ex vivo proved a more sensitive method for detecting drug-related effects after the administration of sulphinpyrazone than collagen-induced platelet aggregation. It was possible to detect...