...Thomas J. Cramer; John H. Griffin; Andrew J. Gale Coagulation factor V (FV) promotes inactivation of activated factor VIII (FVIIIa) by activated protein C (APC) and protein S. Loss of this APC cofactor activity is proposed to be partially responsible for the APC resistance phenotype of FV Leiden...

...Tomohiro Nakagaki; Tatsuya Sueyoshi; Walter Kisiel Previous studies have demonstrated that platelets or aortic endothelial cells provide an appropriate surface that augments the proteolytic inactivation of factor Va by activated protein C (APC). We have examined the ability of three human tumor...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Heparin Activated protein C Bleeding time Bleeding test, in vitro Thrombostat...

...B. Dahlbäck Our laboratory recently found a novel mechanism for thrombophilia, which is characterized by an inherited resistance to activated protein C (APC). The APC-resistance test, which measures the anticoagulant response to APC in an activated partial thromboplasin time (APTT) reaction...

... AT preparations tested, when compared using the same antithrombin unit, had different potencies. Activated protein C (APC) augmented LPS stimulation of HUVEC and further increased the production of tissue factor and IL-6. The same effect was not observed with MNC; LPS-induced tissue factor and IL-6 release were...

... the natural phospholipid composition. Recalcified ft-PRP triggered with 0.5 p M recombinant human tissue factor shows a median thrombin potential of 1,779 n M ·min, against 1,576 n M ·min for fresh PRP. To obtain ∼70% inhibition, 6.7 n M activated protein C (APC) has to be added, instead of 25 n M in fresh...

... of platelet inhibitors (e.g. aspirin and abciximab). Addition of activated protein C (APC) or thrombomodulin inhibits thrombin generation and reflects disorders of the APC system (congenital and acquired resistance, deficiencies and lupus antibodies) independent of concomitant inhibition of the procoagulant...

...Gregorios A. Paspatis; Aikaterini Sfyridaki; Nikolaos Papanikolaou; Kostantinos Triantafyllou; Aikaterini Livadiotaki; Andreas Kapsoritakis; Niki Lydataki Objective: The aim of our study was to determine the frequency of resistance to activated protein C (APC), factor V Leiden (FVL...

... thrombolysis using advanced image analysis software. Mural thrombi were formed by Helium-Neon laser irradiation in mesenteric arterioles and were shown to be lysed, dose-dependently, by smaller amounts of rSAK than those required in venules. Activated protein C (APC), as well as argatroban, enhanced the rSAK...

... in newborns over adult values and has been shown to complex generated alpha-thrombin. In our present study, we point out that a2-M also acts as a procoagulant by inhibiting activated protein C (APC). In all experiments performed in cord and adult plasma the anticoagulant action of APC was diminished in a dose...

...Jari Petäjä; Leena Hakala; Vesa Rasi; John H. Griffin Congenital resistance to activated protein C due to a point mutation in the factor V gene (Gln506-FV) is the most common genetic risk factor for familial venous thrombosis. Considering the central role of activated protein C as a physiological...