... (median 3 vs. 1.5). The splenomegaly group was especially composed of patients who never received any anticoagulant and acetylsalicylic acid, or who used these agents irregularly for very short periods. Conclusion: Splenomegaly was observed in association with disease duration, frequency of thrombotic...

...K. Krupinski; H.K. Breddin Two recombinant hirudins (r-hirudin), natural hirudin and hirudin in combination with heparin or acetylsalicylic acid (ASA) have been studied in a thrombosis model in which rat mesenteric venules of a diameter of 20–30 μm were injured by well-defined argon laser lesions...

... of these measurements with those of 8 volunteers 24 h after they had taken 250 mg of acetylsalicylic acid and those of 5 patients with typical illnesses associated with hypo- and hyperaggregability shows that analysis of the aggregation with two reagent concentrations (1,2 and 4 μg/ml collagen, 1, 2 and 4 μmol/ml ADP...

... was seen to adhere to the vessel wall. Two groups were pretreated with 100 μg/kg nafazatrom and 100 mg/kg acetylsalicylic acid (ASA), both potent antithrombotic drugs. Nafazatrom has been shown to stimulate prostacyclin release from endothelial cells, whereas ASA blocks cyclooxygenase both in platelets...

...R.B. Philp; M.L. Paul Platelets from volunteers were exposed for 1 min to sodium salicylate (SA) before and after the addition of acetylsalicylic acid (ASA) to produce ≥ 50% inhibition of aggregation induced by arachidonic acid (AA) or collagen. SA:ASA concentrations = 20:1. SA protection against...

...Margareta Thorngren; Anders Gustafson; Gertrud Wohlfart The effect of acetylsalicylic acid (ASA) on platelet aggregation before and during a fish diet, already known to decrease the aggregability of platelets and to prolong the bleeding time, was studied in 10 healthy men. Two doses. (3.5 and 10 mg...

... not significantly modify aggregation. Rats treated in vivo with different doses of acetylsalicylic acid or of tranylcypromine, two cyclo-oxygenase inhibitors, abolished the aggregation differences between arterial and venous PRP. It is suggested that this difference in platelet behavior may be due to a mechanism...

...F. Zekert; M. Schemper; K. Neumann In a prospective randomized clinical trial involving 150 patients who underwent major abdominal surgery, acetylsalicylic acid (ASA) and dihydroergotamine (DHE) were examined either alone or in combination for their potential to prevent thromboembolism. Combined...

... was perfused through the chamber of 10 min. Radioactivity of the aorta was measured and found to be mainly caused by the labeled platelets. The platelet deposition on the damaged aorta was measured before and after ingestion of 0.5 g acetylsalicylic acid twice a day for 1 week, and was found to be reduced...

... proportions to acetylsalicylic acid (ASA, 1.5 g/day) (317 patients), placebo (309 patients) or phenprocoumon treatment (320 patients) and followed to determine the incidence of total mortality, coronary death and nonfatal recurrent myocardial infarction. The ASA and placebo groups were treated double-blind...

...Elisabetta Dejana; Aurora Bonaccorsi; Giovanni de Gaetano Acetylsalicylic acid (ASA) did not prevent the arrhythmias induced in rats by a bolus intravenous injection of ADP, an effect independent of platelets. ASA was also unable to protect the rats from the platelet-mediated cardiovascular effects...

...Björn Petruson; Lennart Hahn; Kristoffer Korsan-Bengtsen; Leif Hallberg In a double-blind cross-over study the influence of acetylsalicylic acid (ASA) and paracetamol on menstrual blood loss has been investigated in 23 women without an intrauterine loop or birth control pills. After intake of ASA...

.... Platelet aggregation Ditazole Acetylsalicylic acid Bleeding time Experimental tumors Thrombocytopenia Haemostasis 6: 260-265 (1977) Ditazole and Platelets III. Effect of Ditazole on Tumor-Cell Induced Thrombocytopenia and on Bleeding Time in Mice L. M ussoni, A .P oggi, M .B. Donati and G. de G...

... plus citrate. 15 m M citrate in plasma caused significant reduction of aggregation, thrombus volume and thrombus height; adhesion was concomitantly increased. Heparin (500 U/kg) had no significant effect on adhesion and thrombus dimensions. Treatment of rabbits with acetylsalicylic acid...

...Hans Johnsson; Per Olsson Acetylsalicylic acid and phenylbutazone increased the bleeding significantly from standardized wounds in dogs defibrinogenated with Defibrase. Administration of dipyridamole and Xylocain® had no effect. The results were the same in dogs treated with warfarin sodium...

...Friedel Seuter Effects on platelet aggregation were examined of acetylsalicylic acid (ASA), indomethacin and a number of other agents including dipyridamole, phenylbutazone and sulfinpyrazone under standardized conditions. The Born turbidometric method of measuring platelet aggregation was used...

...Domenico Bottecchia; Glampaolo Fantin; Paolo Gruppo; Gino Nassuato The ionophore for divalent cations, A 23187, induces platelet aggregation and clot retraction. Acetylsalicylic acid has a potentiating effect on the aggregation induced by A 23187 in platelet-rich plasma, while it inhibits...

...H. Vinazzer; J. Pütter; D. Loew The influence of intravenously administered acetylsalicylic acid (ASA) on the kinetics of platelet function was examined in 10 patients. Simultaneously, assays of salicylate in plasma were performed. A significant inhibition of platelet aggregation as well as PF 3...

...D. Loew; H. Vinazzer Lysine salt of acetylsalicylic acid (ASA) was given to ten patients by intravenous infusion. Blood samples taken at intervals during the infusion permitted the examination of the influence of the dose of ASA on platelet functions. Aggregation was significantly reduced when 50...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Platelet aggregation Bleeding time Ditazole Acetylsalicylic acid Haemostasis 6 : 190-196 (1977) Ditazole and Platelets II. Effect of Ditazole on in vivo Platelet...