Heparin was found to inhibit the interaction between human factor VIII and platelets. This was noted in two different systems, namely, platelet aggregation induced by neuraminidase-treated human cryoprecipitate and platelet aggregation induced by ristocetin-human factor VIII complex. Heparin appeared to have an inhibitory effect on the above systems similar to that reported on bovine factor VIII-induced platelet aggregation.

Keywords:
Factor VIII antigen, Ristocetin, Neuraminidase, Platelet aggregation, Platelet agglutination
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© 1977 S. Karger AG, Basel
1977
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