We have determined the minimal concentrations of 4 aggregating agents that were required to cause a 65–75 % increase in light transmission without disaggregation during the 5-min recording period in PRP samples of 14 neonates and 10 adults. We found, for example, that this degree of aggregation could be elicited in adult PRP by a mean value of 2.09 μ M ADP, whereas similar aggregation of neonatal PRP required 5.16 μ M ADP. Based on these figures, we observed that adult PRP was about 2.5 times more sensitive to ADP, at least 10 times to epinephrine and 2.3 times to collagen than neonatal PRP. However, neonatal PRP was approximately 20% more sensitive to ristocetin than adult PRP. By using concentrations of aggregating agents that caused comparable aggregation of neonatal and adult PRP, we noted comparable inhibition of aggregation in these samples by aspirin. While neonatal PRP was less sensitive than adult PRP to physiological aggregating agents, there was no evidence that the former was more susceptible to in vitro aspirin inhibition.

Keywords:
Neonatal and adult PRP, ASA, Threshold concentrations, Aggregating agents
This content is only available via PDF.
© 1977 S. Karger AG, Basel
1977
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.