Type I collagen from calf skin, collagen modified by pepsin treatment, methylation, succinylation or deamidation, as well as the α-chains and cyanogen bromide peptides of the α1-chain, were investigated with respect to their capacity to induce aggregation of human platelets. These preparations permitted an evaluation of the efficacy of the amino acid sequence, triple helical conformation, and various fibrillar structures in platelet aggregation. All collagens in dissolved form (collagen dissolved at acid pH, pep sin-treated, methylated, deamidated, and succinylated collagen) induced platelet aggregation only after fibril formation. The arrangement of molecules within fibrils is of secondary importance. Modification of the side chains of amino acid residues affects primarily the formation of fibrils. The effect of these side chains on platelet aggregation is masked by the overwhelming potency of the fibrillar forms.

Keywords:
Collagen, Collagen peptides, Platelets, Platelet aggregation
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© 1976 S. Karger AG, Basel
1976
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