In an attempt to examine the effect on hemostasis, 20 patients suffering from thrombophlebitis or from postthrombotic syndrome received 10,000 units of heparin and 1.5 g of acetylsalicylic acid (ASA) per day. The scheme of application permitted to distinguish three periods of treatment: heparin, heparin plus ASA and ASA alone. By frequent blood coagulation tests, the alterations of the clotting mechanism during each of these periods were examined. Influences on the plasmatic clotting mechanism were exclusively caused by heparin and were not altered by the addition of ASA. There was, however, a synergistic action of both drugs on the depression of platelet factor 3 availability. Platelet aggregation was enhanced by heparin but could be suppressed by the combined therapy as well as by ASA alone. The overall alterations of hemostasis and coagulation were mild. Even when both drugs were administered simultaneously, the changes were moderate and no clinical signs of hemorrhage could be detected. The purpose of this study was to examine whether a combination of both drugs can be safely applied in an attempt to increase the efficiency of preventive therapy of thromboembolism.

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