Dynamic coagulation-thrombus formation studies and evaluation of the aggregation of red cells, plasma viscosity and blood viscosity were carried out on 22 patients with haemophilia A and 6 patients with Christmas disease. Significant differences are found in the formation and viscosity of artificial red/white and white thrombi between patients with haemophilia A and with Christmas disease.A treatment by plasma infusion or by cryoprecipitate leads to an elevation of plasma viscosity and viscosity of artificial thrombi, and to a decrease of the thrombus formation time. Both types of treatment can be considered equivalent from the rheological point of view. Highly significant correlations are established between the fibrinogen levels and all blood viscosity factors. In particular, fibrinogen level and viscosity of artificial thrombi (p < 0.001), fibrinogen and plasma viscosity (p < 0.001), and fibrinogen and aggregation of red cells (p < 0.01).

Keywords:
Blood viscosity, Haemophilia A, Fibrinogen level, Christmas Disease, Thrombus viscosity, Cryoprecipitate infusion, Plasma infusion
This content is only available via PDF.
© 1973 S. Karger AG, Basel
1973
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.