Fibrinogen degradation products (FDP) interfere with coagulation of fibrinogen and may lead to incorrect estimates of fibrinogen in plasma and of FDP in serum. At pH 7.8 as much as 50–60 % of early FDP were incorporated into clots made from whole blood or from plasma, whereas late FDP were incorporated to minor extent. By lowering pH to 6.3, incorporation of early FDP was markedly reduced. The amount of unclotted fibrin due to the presence of FDP was also reduced. Thus, for a more correct estimate of FDP in serum, it is suggested that pH of blood or plasma should be lowered prior to clotting. Estimation of fibrinogen according to the Jacobsson assay (pH 6.3) is fairly exact in the presence of FDP, except at very high FDP concentrations.

Keywords:
Fibrinogen degradation, products (FDP), Incorporation, Fibrinogen clottability, Tracer technique
This content is only available via PDF.
© 1973 S. Karger AG, Basel
1973
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.