We studied platelet survival in 14 cardiac patients before heart valve replacement using 75Se-methionine ‘cohort label’. The temporal variation of plasma and platelet activity was plotted by a continuous curve by means of a computerized interaction of the single points. Then we computed the plasmatic radioactivity fraction used daily for thrombo-poiesis and made a subtraction of this aliquot from the experimental activity in the catabolic phase of the slope. Platelet life span obtained after this ‘correction’ is comparable with the values of random label using 51Cr.

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