Background: Common malignant tumors of the urinary system include renal cell carcinoma, bladder carcinoma, and prostate cancer. The research on the CYP24A1 gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. Therefore, we selected bladder cancer, prostate cancer, and renal cancer as the research objects to explore the influence of CYP24A1 on the genetic susceptibility of urinary system tumors. Materials and Methods: rs6068816, rs2296241, rs2762934, and rs1570669 in 529 patients and 523 controls were genotyped via the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of two SNPs with susceptibility of urinary system cancer. Database predicts the expression of the CYP24A1 gene in urinary system cancer. Results: Individuals with the AG genotype of CYP24A1 rs1570669 has a 28% lower risk of developing urinary system tumors (OR = 0.72, 95% CI: 0.56–1.13, p = 0.016) and has a 31% lower risk of developing renal cancer (OR = 0.69, 95% CI: 0.51–0.92, p = 0.012). Conclusions:CYP24A1 rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.

1.
Bray
F
,
Ferlay
J
,
Soerjomataram
I
,
Siegel
RL
,
Torre
LA
,
Jemal
A
.
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
.
CA Cancer J Clin
.
2018
;
68
:
394
424
.
2.
Siegel
RL
,
Miller
KD
,
Jemal
A
.
Cancer statistics, 2018
.
CA Cancer J Clin
.
2018
;
68
:
7
30
.
3.
Patel
NH
,
Attwood
KM
,
Hanzly
M
,
Creighton
TT
,
Mehedint
DC
,
Schwaab
T
, et al
Comparative analysis of smoking as a risk factor among renal cell carcinoma histological subtypes
.
J Urol
.
2015
;
194
:
640
6
.
4.
van Osch
FH
,
Jochems
SH
,
van Schooten
FJ
,
Bryan
RT
,
Zeegers
MP
.
Significant role of lifetime cigarette smoking in worsening bladder cancer and upper tract urothelial carcinoma prognosis: a meta-analysis
.
J Urol
.
2016
;
195
:
872
9
.
5.
Botteri
E
,
Ferrari
P
,
Roswall
N
,
Tjonneland
A
,
Hjartaker
A
,
Huerta
JM
, et al
Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort
.
Int J Cancer
.
2017
;
141
:
1963
70
.
6.
Ma
Y
,
Johnson
CS
,
Trump
DL
.
Mechanistic insights of vitamin D anticancer effects
.
Vitam Horm
.
2016
;
100
:
395
431
.
7.
Dou
R
,
Ng
K
,
Giovannucci
EL
,
Manson
JE
,
Qian
ZR
,
Ogino
S
.
Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence
.
Br J Nutr
.
2016
;
115
:
1643
60
.
8.
Jacobs
ET
,
Van Pelt
C
,
Forster
RE
,
Zaidi
W
,
Hibler
EA
,
Galligan
MA
,
Haussler
MR
, et al
CYP24A1 and CYP27B1 polymorphisms modulate vitamin D metabolism in colon cancer cells
.
Cancer Res
.
2013
;
73
:
2563
73
.
9.
Yao
S
,
Zirpoli
G
,
Bovbjerg
DH
,
Jandorf
L
,
Hong
CC
,
Zhao
H
, et al
Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study
.
Breast Cancer Res
.
2012
;
14
:
R58
.
10.
Fuhrman
BJ
,
Freedman
DM
,
Bhatti
P
,
Doody
MM
,
Fu
YP
,
Chang
SC
, et al
Sunlight, polymorphisms of vitamin D-related genes and risk of breast cancer
.
Anticancer Res
.
2013
;
33
:
543
51
.
11.
Wang
P
,
Zhang
H
,
Zhang
Z
,
Qin
L
,
Li
B
.
Association of the CYP24A1-rs2296241 polymorphism of the vitamin D catabolism enzyme with hormone-related cancer risk: a meta-analysis
.
Onco Targets Ther
.
2015
;
8
:
1175
83
.
12.
Yang
W
,
Ma
F
,
Wang
L
,
He
X
,
Zhang
H
,
Zheng
J
, et al
The association analysis between CYP24A1 genetic polymorphisms and the risk of ischemic stroke in Chinese Han population
.
Brain Behav
.
2020
;
10
:
e01503
.
13.
Li
M
,
Li
A
,
He
R
,
Dang
W
,
Liu
X
,
Yang
T
, et al
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility
.
Cancer Med
.
2019
;
8
(
10
):
4892
905
.
14.
Thomas
RK
,
Baker
AC
,
Debiasi
RM
,
Winckler
W
,
Laframboise
T
,
Lin
WM
, et al
High-throughput oncogene mutation profiling in human cancer
.
Nat Genet
.
2007
;
39
:
347
51
.
15.
Gabriel
S
,
Ziaugra
L
,
Tabbaa
D
.
SNP genotyping using the Sequenom MassARRAY iPLEX platform
.
Curr Protoc Hum Genet
.
2009 Jan
;Chapter 2:Unit 2.12.
16.
Guo
T
,
Hao
H
,
Zhou
L
,
Zhou
F
,
Yu
D
.
Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population
.
Oncotarget
.
2018
;
9
:
4698
706
.
17.
Adamec
C
.
[Example of the use of the nonparametric test. test x2 for comparison of 2 independent examples]
.
Cesk Zdrav
.
1964
;
12
:
613
9
.
18.
Bland
JM
,
Altman
DG
.
Statistics notes. The odds ratio
.
BMJ
.
2000
;
320
:
1468
.
19.
Barrett
JC
,
Fry
B
,
Maller
J
,
Daly
MJ
.
Haploview: analysis and visualization of LD and haplotype maps
.
Bioinformatics
.
2005
;
21
:
263
5
.
20.
King
AN
,
Beer
DG
,
Christensen
PJ
,
Simpson
RU
,
Ramnath
N
.
The vitamin D/CYP24A1 story in cancer
.
Anticancer Agents Med Chem
.
2010
;
10
:
213
24
.
21.
Luo
W
,
Hershberger
PA
,
Trump
DL
,
Johnson
CS
.
24-Hydroxylase in cancer: impact on vitamin D-based anticancer therapeutics
.
J Steroid Biochem Mol Biol
.
2013
;
136
:
252
7
.
22.
O’Seaghdha
CM
,
Wu
H
,
Yang
Q
,
Kapur
K
,
Guessous
I
,
Zuber
AM
, et al
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations
.
PLoS Genet
.
2013
;
9
:
e1003796
.
23.
Muindi
JR
,
Nganga
A
,
Engler
KL
,
Coignet
LJ
,
Johnson
CS
,
Trump
DL
.
CYP24 splicing variants are associated with different patterns of constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines
.
J Steroid Biochem Mol Biol
.
2007
;
103
:
334
7
.
24.
Fuqiang
C
,
Qingshu
L
,
Yang
Y
,
Wenrong
Y
,
Fei
S
,
Yan
Q
.
Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis
.
Sci Rep
.
2015
;
5
:
9599
.
25.
Tretli
S
,
Hernes
E
,
Berg
JP
,
Hestvik
UE
,
Robsahm
TE
.
Association between serum 25(OH)D and death from prostate cancer
.
Br J Cancer
.
2009
;
100
:
450
4
.
26.
Guangzheng
L
,
Ling
N
,
Di
G
,
Shi
L
,
Zhe
Y
,
Qicheng
L
, et al
Examining the association of circulating 25-hydroxyvitamin D with kidney cancer risk: a meta-analysis
.
Int J Clin Exp Med
.
2015
;
8
(
11
):
20499
507
.
27.
Jones
G
,
Prosser
DE
,
Kaufmann
M
.
25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D
.
Arch Biochem Biophys
.
2012
;
523
:
9
18
.
28.
Tang
Z
,
Li
C
,
Kang
B
,
Gao
G
,
Li
C
,
Zhang
Z
.
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
.
Nucleic Acids Res
.
2017
;
45
:
W98
102
.
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