Background/Aims: Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels - approved by regulatory agencies - and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists. Methods: We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics. Results and Conclusions: A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases.

Keywords:
Databases, Data interpretation, Data querying, Drug, Gene, Pharmacogenomics
1.
Vogel F: Moderne Probleme der Humangenetik. Ergeb Inn Med U Kinderheilk 1959;12:52-125.
2.
Weinshilboum R: Inheritance and drug response. N Engl J Med 2003;348:529-537.
3.
Maliepaard M, Nofziger C, Papaluca M, Zineh I, Uyama Y, Prasad K, Grimstein C, Pacanowski M, Ehmann F, Dossena S, Paulmichl M: Pharmacogenetics in the evaluation of new drugs: a multiregional regulatory perspective. Nat Rev Drug Discov 2013;12:103-115.
4.
Thorn CF, Klein TE, Altman RB: PharmGKB: the Pharmacogenomics Knowledge Base. Methods Mol Biol 2013;1015:311-320.
5.
Bell M: SOA Modeling Patterns for Service-Oriented Discovery and Analysis. Hoboken, Wiley & Sons, 2010.
6.
Papadopoulos P, Viennas E, Gkantouna V, Pavlidis C, Bartsakoulia M, Ioannou ZM, Ratbi I, Sefiani A, Tsaknakis J, Poulas K, Tzimas G, Patrinos GP: Developments in FINDbase worldwide database for clinically relevant genomic variation allele frequencies. Nucleic Acids Res 2014;42:D1020-D1026.
7.
Potamias G, Lakiotaki K, Katsila T, Lee M, Topouzis S, Cooper DN, Patrinos GP: Deciphering next-generation pharmacogenomics: an information technology perspective. Open Biol 2014;4:140071.
8.
Georgitsi M, Viennas E, Gkantouna V, Christodoulopoulou E, Zagoriti Z, Tafrali C, Ntellos F, Giannakopoulou O, Boulakou A, Vlahopoulou P, Kyriacou E, Tsaknakis J, Tsakalidis A, Poulas K, Tzimas G, Patrinos GP: Population-specific documentation of pharmacogenomic markers and their allelic frequencies in FINDbase. Pharmacogenomics 2011;12:49-58.
© 2014 S. Karger AG, Basel
2014
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