...Simon Lerch; Joerg C. Schefold; Thibaud Spinetti Background: The enzyme indolamine-2,3-dioxygenase 1 (IDO1) is the rate-limiting enzyme of the kynurenine (KYN) pathway and metabolizes the essential amino acid tryptophan to KYNs. The depletion of tryptophan and the generation of KYNs were shown...

...Melvin J. Fregly; Ora E. Lockley; Jose L. Torres; Robert Cade Chronic dietary administration of either /-tryptophan (5.0%) or nicotinic acid (5.0%) reduced the elevated blood pressure of rats with established, deoxycorticosterone-acetate (DOCA)-salt-induced hypertension without affecting either...

...Melvin J. Fregly; Ora E. Lockley; Robert Cade Chronic dietary administration of L-tryptophan (2.5 and 5.0 g/100 g food) to rats provided significant protection against the development of hypertension induced by bilateral encapsulation of the kidneys with latex envelopes. Lower doses of tryptophan...

... behavioral tests. The maximally effective dose of Δ 9 -THC (30 mg/kg) in this test also increased the amount of 3 H-tryptophan found in the brains of mice given an intravenous injection of 3 H-tryptophan 10 min prior to decapitation. This effect was associated with an increase in the amount of 3 H-5...

...Robert B. Sanders; Viswanathan Sagur The administration of L -tryptophan prevented the normal rise in blood sugar concentration that usually follows the injection of epinephrine into rats. Of the several possible mechanisms by which tryptophan could inhibit epinephrine-induced hyperglycemia, one...

... or decreasing serotonin turnover in the brain with either a serotonin precursor (tryptophan) or the inhibitors of serotonin re-uptake (Lilly 110140 and chlorimipramine) also greatly enhanced the CPZ-induced hypothermia. The data indicate that serotonergic activity in the brain plays a role in the elaboration...

...Kenneth M. Johnson; William L. Dewey The in vitro addition of (–)-Δ 9 -tetrahydrocannabinol (Δ 9 -THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3 H-tryptophan and 3 H-choline in mouse forebrain crude synaptosomal preparations...

...Robert B. Sanders; Viswanathan Sagur Measurements of 3-O-methyl glucose (3-O-MG) transport were undertaken in order to determine whether a specific concentration of tryptophan stimulated glucose transport into peripheral tissues of the rat and might, thereby, prevent epinephrine-induced...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Tryptophan Epinephrine Hyperglycemia in rats Inhibition of hyperglycemia 24 11 1969 27 5 2008 Pharmacology 3: 305-314 (1970) Tryptophan Epinephrine Hyperglycemia in rats Inhibition...

...P.T.-H. Wong; Y.P. Ong The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p -chlorophenylalanine ( p -CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively. Single-dose...