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Keywords: Tryptophan
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2022) 107 (7-8): 359–367.
Published Online: 12 April 2022
...Simon Lerch; Joerg C. Schefold; Thibaud Spinetti Background: The enzyme indolamine-2,3-dioxygenase 1 (IDO1) is the rate-limiting enzyme of the kynurenine (KYN) pathway and metabolizes the essential amino acid tryptophan to KYNs. The depletion of tryptophan and the generation of KYNs were shown...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (2): 91–100.
Published Online: 05 June 2008
...Melvin J. Fregly; Ora E. Lockley; Robert Cade Chronic dietary administration of L-tryptophan (2.5 and 5.0 g/100 g food) to rats provided significant protection against the development of hypertension induced by bilateral encapsulation of the kidneys with latex envelopes. Lower doses of tryptophan...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1981) 23 (4): 223–229.
Published Online: 30 May 2008
... behavioral tests. The maximally effective dose of Δ 9 -THC (30 mg/kg) in this test also increased the amount of 3 H-tryptophan found in the brains of mice given an intravenous injection of 3 H-tryptophan 10 min prior to decapitation. This effect was associated with an increase in the amount of 3 H-5...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1978) 17 (2): 83–87.
Published Online: 29 May 2008
...Kenneth M. Johnson; William L. Dewey The in vitro addition of (–)-Δ 9 -tetrahydrocannabinol (Δ 9 -THC) resulted in a dose-responsive inhibition of the high-affinity specific synaptosomal uptake of both 3 H-tryptophan and 3 H-choline in mouse forebrain crude synaptosomal preparations...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1968) 18 (3): 128–135.
Published Online: 29 May 2008
... or decreasing serotonin turnover in the brain with either a serotonin precursor (tryptophan) or the inhibitors of serotonin re-uptake (Lilly 110140 and chlorimipramine) also greatly enhanced the CPZ-induced hypothermia. The data indicate that serotonergic activity in the brain plays a role in the elaboration...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1978) 16 (6): 321–332.
Published Online: 29 May 2008
...Robert B. Sanders; Viswanathan Sagur The administration of L -tryptophan prevented the normal rise in blood sugar concentration that usually follows the injection of epinephrine into rats. Of the several possible mechanisms by which tryptophan could inhibit epinephrine-induced hyperglycemia, one...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1970) 3 (5): 305–314.
Published Online: 27 May 2008
... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Tryptophan Epinephrine Hyperglycemia in rats Inhibition of hyperglycemia Pharmacology 3: 305-314 (1970) Tryptophan Epinephrine Hyperglycemia in rats Inhibition...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2001) 62 (3): 151–156.
Published Online: 30 March 2001
...P.T.-H. Wong; Y.P. Ong The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p -chlorophenylalanine ( p -CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively. Single-dose...