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Keywords: Toxic metabolite
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (1974) 12 (4-5): 251–271.
Published Online: 28 May 2008
... and Lung Institute, National Institutes of Health, Bethesda, Md. Key Words. Acetaminophen Glutathione Liver necrosis Mercapturic acid Toxic dose threshold Toxic metabolite Abstract. The relationship between the metabolic disposition of acetaminophen and the susceptibility of hamsters, mice...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1974) 11 (3): 151–169.
Published Online: 28 May 2008
... metabolite dence that 3,4-bromobenzene oxide is the reactive hepato­ toxic metabolite. The studies also demonstrate that the hepatotoxic metabolite is preferen­ tially conjugated (detoxified) with glutathione, thereby depleting glutathione from the liver. Liver necrosis and arylation of cellular...