...Hemendra N. Bhargava; George A. Matwyshyn The effect of dizocilpine (MK-801), an N-methyl- D -aspartate receptor antagonist, on the development of tolerance to the analgesic and hyperthermic effects of morphine was determined in the rat. Tolerance to morphine in male Sprague-Dawley rats was induced...

... sacrificed 1 h later (tolerant-dependent rats). In another, the rats were sacrificed 16 h after the last injection of U-50,488H (abstinent rats). Chronic administration of U-50,488H resulted in the development of tolerance to its analgesic effect, as demonstrated by the decreased response to a challenge dose...

...Magaly Wainstein; Mario Tannhauser; Helena M.T. Barros Few clinical reports describe tolerance induced by antidepressants and this question is considered an unsolved problem for clinical use of this group of drugs. The present report deals with the effects of imipramine and mianserine on two animal...

... of tolerance to the analgesic effect of morphine. 5 02 1986 7 07 1986 5 6 2008 © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form...

... with rapid development of tolerance to the hypothermic action of this drug. A single injection of apomorphine resulted in significant (p < 0.01) decrease of AChE and significant increase of ChAT activity (p < 0.01) in the cortex, hypothalamus and pons. There were no significant differences between...

...) on days 1, 3, 8, 15, and 23 did not alter the magnitude of the temperature change compared to that following the first injection, i.e., neither tolerance nor potentiation occurred. 15 08 1989 8 11 1989 5 6 2008 © 1990 S. Karger AG, Basel 1990 Copyright / Drug Dosage / Disclaimer...

...Monique Ben-Am; Amos D. Korczyn The occurrence of cross-tolerance between morphine and met-enkephalin, and between morphine and DADL ( D -Ala- D -Leu-enkephalin) in causing mydriasis in mice was studied. Morphine-tolerant mice treated with met-enkephalin or DADL intracerebroventric-ularly (ICV...

.... Moreover, such a decrease in K d in morphine-treated rats persisted even 24 h after removal of morphine pellets. The effect of prolyl-leucyl-glycinamide (MIF; 2 mg/kg), which has been shown to inhibit the development of tolerance to and dependence on morphine, on the changes in the binding of 3H-NPA...

... on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism...

... a cytochrome P-450-deρendent monooxygenase which synthesizes catecholamphetamine from p-hydroxyamphetamine. The formation of this catechol metabolite may be involved in the development of tolerance in chronic amphetamine use. 29 5 2008 © 1979 S. Karger AG, Basel 1979 Copyright / Drug Dosage...

... to morphine in both nontolerant and tolerant rats and accelerated the development of tolerance to morphine. These results may provide further evidence for a role of cAMP in the mediation of the central actions of morphine. © 1978 S. Karger AG, Basel 1978 Copyright / Drug Dosage / Disclaimer Copyright...

...Şükrü Kaymakçalan; Şemuel Sivil Acute and chronic effects of Δ 9 -tetrahydrocannabinol (THC) on the heart rate were studied in unanesthetized rats. THC produced a negative chronotropic effect. Contrary to the many other effects of THC, tolerance did not develop to the bradycardic effect after 16...

... Phenobarbital Physical dependence Tolerance Pharmacology 10: 169-177 (1973) Thresholds for Electro- and Chemoconvulsions in Mice after Termination of Treatment with Phénobarbital Marion Kilian and H.-H. Frey1 Department of Pharmacology and Toxicology, School of Veterinary Medicine, Free University, Berlin...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cannabinoid Hypothermia Tolerance Pharmacology 15: 233-241 (1977) Hypothermia in Rats Produced by Nabilone...

...E.A. Carlini 29 01 1968 27 5 2008 Pharmacology 1: 135-142 (1968) cannabis sativa marihuana tolerance behaviour Tolerance to Chronic A dm inistration of Cannabis sativa (M arihuana) in R ats1 E. A. Cari.ini Departamento de Ciencias Fisiológicas, Faculdade de Medicina da Santa Casa...

...Zhi Jun Ge; Li Cai Zhang; Yin Ming Zeng; Ti Jun Dai; Li Chang; Jun Ke Wang; Guo Xin Cui; Yong Fei Tan; Yan Ping Zhao; Guo Jun Liu The present study evaluated the role of ventrolateral periaqueductal gray (vlPAG)-located orphanin-FQ (OFQ) in the opioid tolerance induced by repeated microinjections...

... traditionally been interpreted as reflecting the development of tolerance to the drug’s effects. However, on the basis of animal behavioral data, several groups have recently proposed alternative explanations, i.e. that such an escalation of drug use might not be based on (1) tolerance, but rather be indicative...

...Vijay Pal Singh; Chandrashekhar S. Patil; Naveen K. Jain; Amarjit Singh; Shrinivas K. Kulkarni Selective serotonin reuptake inhibitors (SSRIs) have been used clinically as co-analgesics in various devastating painful conditions. Upon chronic treatment tolerance develops to their analgesic effect...

...Shyam Sunder Sharma; Hemendra N. Bhargava The effects of ibogaine, an alkaloid isolated form the bark of the African shrub, Tabernathe iboga , and noribogaine, a metabolite of ibogaine, on morphine antinociception were determined in male Swiss-Webster mice. Mice were rendered tolerant to morphine...