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Keywords: TGR5 receptor
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Journal Articles

Pregnane-Oximino-Alkyl-Amino-Ether Compound as a Novel Class of TGR5 Receptor Agonist Exhibiting Antidiabetic and Anti-Dyslipidemic Activities

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Subject Area:
Pharmacology
Jyoti Gupta, Dharmendra P. Singh, Prem C. Verma, Neha Rahuja, Rohit Srivastava, Ishbal Ahmad, Natasha Jaiswal, Harish Kumar, Anand P. Gupta, Varsha Gupta, Anamika Misra, Hari N. Kushwaha, Bhawani Singh, Sheo K. Singh, Anil K. Dwivedi, Jiaur R. Gayen, Sabyasachi Sanyal, Arvind K. Srivastava, Ram Pratap, Akhilesh K. Tamrakar
Journal: Pharmacology
Pharmacology (2022) 107 (1-2): 54–68.
https://doi.org/10.1159/000519721
Published Online: 23 November 2021
... associated with the activation of the G-protein-coupled bile acid receptor TGR5. Conclusion: Compound 14b exhibits antidiabetic and anti-dyslipidemic activities through activating the TGR5 receptor system and can be developed as a lead for the management of type II diabetes and related metabolic...
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