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Keywords: Streptozotocin
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2020) 105 (9-10): 576–585.
Published Online: 25 February 2020
... model by streptozotocin (STZ) administration and high-glucose-high-fat diet. Results: The rats with T2DM showed severe insulin resistance, left ventricular dysfunction, aberrant lipids deposition, cardiac inflammation, and fibrosis compared with the control group. All these pathological symptoms were...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2008) 82 (3): 193–200.
Published Online: 23 September 2008
... in a streptozotocin (STZ)-induced neuropathic model was investigated. When administered alone, a non-selective cannabinoid receptor agonist, WIN 55,212-2, a potentially selective CB-1 cannabinoid receptor agonist, Met-F-AEA, and a selective CB-2 cannabinoid receptor agonist, AM1241, dose-dependently reduced STZ...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2008) 82 (3): 180–186.
Published Online: 14 August 2008
...Magdalena Bujalska; Ewelina Malinowska; Helena Makulska-Nowak; Stanisław Witold Gumułka Streptozotocin-induced hyperglycemia accompanied by a chronic decrease in the nociceptive threshold is considered a useful model of experimental hyperalgesia. We examined (1) the effect of the opioid receptor...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (2): 69–73.
Published Online: 10 June 2008
...Y. Tanaka; H. Shimizu; N. Sato; M. Mori; Y. Shimomura The exact mechanism by which streptozotocin (STZ) destroys pancreatic β-cells has not been determined. Recently, nitric oxide was identified as a potent islet toxic compound. However, nitric oxide production by STZ has not been proved yet...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 46 (2): 101–108.
Published Online: 06 June 2008
...-Adrenoceptors Isoproterenol Diabetes mellitus Streptozotocin Calcium channel activator Cardiomyopathy Rat © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1987) 34 (2-3): 143–148.
Published Online: 05 June 2008
...Melih Altan; Nuray Yildizoğlu; Yusuf Öztürk In this study, the β-adrenergic, muscarinic and serotonergic receptor activities were investigated in alloxan- and streptozotocin-diabetic rats using duodenum, ileum and gastric fundus strips as assay organs. In addition, the effect of manganese chloride...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 37 (5): 281–285.
Published Online: 05 June 2008
... of glucose (5.04 g/kg), while chronic hyperglycemia was induced by streptozotocin injection (200 mg/kg i.p., 7–8 days before). Acute hyperglycemia augmented the inhibitory effect of morphine on gut transit, however, chronic hyperglycemia failed to modify the effects of morphine. The results indicate...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1983) 27 (3): 130–139.
Published Online: 04 June 2008
...S. Ramanadham; T.E. Tenner, Jr. Responses in cardiac tissue isolated from streptozotocin (STZ)-treated and age-matched control rats to isoproterenol (ISO) and calcium were studied. 4 weeks after STZ, atrial function was found to be depressed, whereas right ventricular function was enhanced. Neither...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1980) 21 (3): 223–228.
Published Online: 30 May 2008
...C.L Kaul; R.S. Grewal An attempt has been made to measure changes in the endogenous noradrenaline contents of hearts and brains in rats made diabetic by intravenous administration of streptozotocin. There was no significant change in the endogenous noradrenaline content in the hearts and brains...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1971) 6 (3): 129–136.
Published Online: 28 May 2008
...S. Weinstein; S.B. Gertner The ability of varying doses of streptozotocin to produce diabetes mellitus in cats was assessed. Doses up to and including 200mg/kg did not induce diabetes, but did impair the glucose tolerance of the animals. Certain neurological symptoms appeared with doses higher than...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2007) 80 (4): 227–238.
Published Online: 06 July 2007
...Isil Ozakca; Ebru Arioglu; Sahika Guner; V. Melih Altan; A. Tanju Ozcelikay The contribution of β-adrenoceptor subtypes to the catecholamine-mediated relaxations in gastric fundus from control and streptozotocin (STZ)-induced diabetic rats were investigated. Isolated organ bath studies...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2007) 79 (4): 243–249.
Published Online: 23 April 2007
...Md. Shahidul Islam; Haymie Choi Seven-week-old male Sprague-Dawley (SD) rats were divided into six groups (LFC, LFD, HFC, HFD30, HFD40, HFD50) to determine whether animals receiving a low-fat (LF) diet plus nicotinamide-streptozotocin (NA-STZ) injection or animals receiving a high-fat (HF) diet...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2006) 76 (2): 69–75.
Published Online: 25 January 2006
... is involved in the etiology of diabetic nephropathy. Resveratrol, a polyphenolic phytoalexin present in red wine, is known to possess potent antioxidant properties and thus we aimed to examine its effect on renal function and oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced...
Journal Articles
Journal Articles