... indicate that the anti-dysmenorrhea effect of nanoCARV may be related to the relaxation of uterine smooth muscle, with participation of the cAMP signaling pathway and potassium channels. [email protected] 4 05 2023 16 11 2023 19 12 2023 © 2023 S. Karger AG...

..., vascular smooth muscle and nerve fibers. However, little is known about the physiological role of NCX1 in gastrointestinal motility. To determine the role of NCX1 in gastrointestinal tissues, we examined electric field stimulation (EFS)-induced responses in the longitudinal smooth muscle of the distal...

...Lorand Bartho; Zsolt Sándor; Dezsö Kelemen; Robert Papp; Rita Benko AP-18, a putative antagonist at TRPA1 receptor/ion channel, caused smooth muscle relaxation at 10-100 µmol/l. It inhibited cholinergic twitch responses evoked by electrical field stimulation of cholinergic nerves as well...

...Sun Young Park; Sung Uk Park; Uy Dong Sohn In this study, we investigated the components of electrical field stimulation (EFS)-induced responses and the intracellular factors that mediate electrically stimulated responses in feline distal esophageal smooth muscles. Muscle contractions were recorded...

... Benzofuroindole LDD175 Overactive bladder BKCa channel opener Smooth muscle Hemodynamic activity Spontaneously hypertensive rats Abstract The present study describes the bladder-relaxant properties of LDD175 (4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo [3,2-b]indole-1-carboxylic acid), a novel...

... of smooth muscle. Original Paper Pharmacology 1993;47:300-308 Michiyo Toyoda Norio Ogata Takashi Shibata Research Institute, Taiko Pharmaceutical Co., Ltd., Osaka, Japan Suppression of Intestinal Smooth Muscle Contraction by 4-Ethylguaiacol, a Constituent of Wood Creosote Key Words 4-Ethylguaiacol Wood...

..., Bulgaria Effects of Cobalt or Nickel on the Sympathetically Mediated Contractile Responses in RaMsolated Vas deferens Key Words Cobalt Nickel Sympathetic synapse Smooth muscle Adrenoceptors Purinoceptors Cotransmission Vas deferens Abstract Subchronic (30 days) exposure of rats to Co(NC>3)2 or NiSQ* (20 mg...

...Stephen A. Zderic; Guo-Hua Liu; Jean P. Haab; Frederick C. Monson; Chiaoliang Gong; Robert M. Levin There is often disagreement over the optimal method by which to study the active properties of smooth muscle. While some favor setting smooth muscle strips at a resting or passive tension of 1 g...

...Kenro Imaeda; Hikaru Hashitani; Lin Xue; Yoshimichi Yamamoto; Makoto Itoh; Hikaru Suzuki Electrophysiological experiments were carried out to investigate the prokînetic actions of DQ-2511 on isolated smooth muscle of the guinea pig stomach. DQ-2511 enhanced the myogenic gastric slow waves...

..., but resistant to atropine, tetrodotoxin or ondansetron. In conclusion, this study provides evidence that: (1) erythromycin is a prokinetic drug at the colonic level in rabbits, and (2) both in vivo and in vitro, the effects of erythromycin are exerted at the smooth muscle level by mechanisms depending on influx...

..., but not in the urinary bladder. At the concentrations used, the effect of SR 58611A was probably mediated solely by activation of β 3 -adrenoceptors located on smooth muscle cells, whereas the effects of isoprenaline were due to β 3 - and also to β 1 - and/or β 2 -adrenoceptor activation. β-Adrenoceptors Smooth...

..., instructions or products referred to in the content or advertisements. NK-3 receptor antagonist SR 142801 Smooth muscle Pharmacology Original Paper Pharmacology 1996;52:283-291 X. K. Nguyen-Lea Q.T. Nguyena F. Gobeila L.H. Phenga X. Emonds-Alta J.C. Brelièreb D. Regolia Pharmacological...

.... Ruggieri, Robert M. Levin Division of Urology, University of Pennsylvania School of Medicine and the Philadelphia Veterans Administration Medical Center, Philadelphia, Pa., USA Key Words. Urinary bladder Imipramine Smooth muscle Abstract. Imipramine is a tricyclic antidepressant that has been...

... described in this paper provide important tools for pharmacological studies on NK. Substance P Neurokinins Smooth muscle Antagonists Neurokinin-2 receptor Pharmacology 1990;41:184-194 © 1990 S. Karger AG, Basel 0031 -7012/90/0414-0184S2.75/0 Structure-Activity Study of Neurokinins: Antagonists...

... required the presence of intact endothelium, while VIP did not. The effect of VIP did not appear to be mediated by catecholamines. Simultaneous measurements of intracellular membrane potential and tension developed by coronary smooth muscle precontracted with Ach showed that the smooth muscle relaxation...

..., instructions or products referred to in the content or advertisements. Cadmium Smooth muscle Tenia coli Anoxia Pharmacology JO: 281-288 (1985) © 1985 S. Karger A G . Basel 0031-7012/85/0305-0281 S2.75/0 Metabolic Dependency of Cadmium Uptake and the Relaxant Effects of Cadmium in Smooth Muscle...

... or aorta, respectively. Tetrodotoxin and saxitoxin (both 5 × 10 –7 M ) also abolished the responses to BTX-B in the both tissues. Results suggest that BTX-B produces smooth muscle contractions through the tetrodotoxin- and saxitoxin-sensitive release of transmitters from autonomic nerves. 7 01 1985...

...)test for inhibition of mast cell histamine release, secondary to a passive anaphylactic response on human lung tissue; (2) determination of the type of interference with the contracting effects of bradykinin, acetylcholine and serotonin; (3) interference with the smooth muscle contraction induced...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Peptides Kinins Substance P Smooth muscle Isolated vessels Blood pressure Myotropic actions 30 5 2008...

... for precise pharmacological studies on peptides because: (a) the sensitivity of the longitudinal colon strip to various stimulants increases progressively during in vitro incubation; (b) stimulants and inhibitors act not only on the smooth muscle fibers but also on the three functionally distinct sections...