... of locomotor activity. STAT6-deficient mice exhibited a significantly enhancing dopamine and 5-hydroxytryptamine (5-HT, serotonin) in brain. In addition, the expression of serotonin transporter in the hippocampus was markedly downregulated in STAT6-deficient mice. These results provide the first evidence...

... interaction in OBX mice, whereas only weak synergistic effects on cognitive performance were seen. To address mechanisms underlying these effects, we used in vivo microdialysis study and observed impaired nicotine-induced serotonin (5-HT) release in OBX mouse hippocampus. Combined memantine/donepezil...

.... Coronary circulation Rat coronary arteries Serotonin 5-HT 2 receptor Ageing Original Paper Pharmacology 2012;90:160 168 DOI: 10.1159/000341722 Received: June 20, 2012 Accepted after revision: July 4, 2012 Published online: August 22, 2012 Effect of Ageing on the Passive and Active Tension...

..., and increased serotonin and dopamine levels in the brain tissues. A subeffective dose (50 mg/kg) of these formulations enhanced the antidepressant-like effect of classical antidepressants with varied mechanisms of action. In addition, an SJW dose of 25 mg/kg showed a significant antidepressant-like effect...

... compounds do not always correspond to their established receptor subtype selectivity. Here, we assessed the effects of SKF 38393 and SCH 23390 on the synaptosomal uptake of tritiated serotonin. Methods: Uptake experiments were performed by using [ 3 H]serotonin and synaptosomal fractions prepared from...

...Matthew Goddard; Paul F. Smith; John C. Ashton Previous studies have suggested panic induced by cannabinoids may be potentiated by concurrently using selective serotonin reuptake inhibitors. We therefore tested for panic and anxiety-related behaviour in rats coadministered with the selective...

...Brian Hall; Andrea Burnett; Alicia Christians; Cortney Halley; Eric Goldstein; Harish V. Thiagaraj; Keith K. Parker The human serotonin 1a receptor (H5HT1aR) is a highly studied member of the 7 transmembrane G protein-coupled receptors. This model receptor, negatively coupled to adenylyl cyclase...

...Susann Matthes; Valentina Mosienko; Saleh Bashammakh; Natalia Alenina; Michael Bader Serotonin (5-HT) is a monoamine implicated in a variety of physiological processes that functions either as a neurotransmitter or as a peripheral hormone. Pharmacological and genetic studies in humans...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Serotonin 5-Hydroxytryptamine 2...

...Nergis Murat; Burak Cem Soner; Omer Demir; Adil Esen; Sedef Gidener Background/Aims: Serotonin (5-hydroxytryptamine, 5-HT)-induced contraction and the involvement of RhoA/Rho-kinase pathway in the 5-HT-induced contraction was investigated isometrically in vitro in both diabetic and nondiabetic...

...Philippe Girard; Yannick Pansart; Marie-Claude Coppé; Betty Niedergang; Jean-Marie Gillardin Background/Aims: Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT 3 receptor antagonists, but these drugs can...

... and motor propulsion that acts to clear the antigenic threat from the colonic lumen. Histamine and serotonin are important chemical messages released from mucosal mast cells to act at specific receptor subtypes on neural elements of the enteric minibrain. Pharmacology Pharmacology 1993;47(suppl 1):7 13 J.D...

...E. Beubler; A. Schirgi-Degen The aim of this study was to investigate whether 5-hydroxy-tryptamine (serotonin, 5-HT) is involved in the mediation of sennoside-induced colonic fluid secretion and diarrhea. Oral administration of purified sennosides (25, 40 and 64 mg/kg) dose-dependently reversed net...

...M.A. Noguera; M.P. D’Ocon Serotonin 1 μmol/l induces a contractile response in the isolated rat aorta in both the presence or absence of extracellular Ca. The present study analyzes the influence of temperature and caffeine on subsequent serotonin-induced contractions. In Ca-free medium...

...Bahjat A. Faraj; Zbigniew L. Olkowski; Richard T. Jackson The main objective of the present investigation was to determine whether the uptake of [ 3 H]-dopamine in human lymphocytes is mediated through a serotonin transporter. This was examined by studying the effects of various monoamine uptake...

...) stimulation of the serotonergic system in general stimulates morphine preference, (4) the serotonin system does not affect nicotine or cocaine preference and (5) the serotonergic system is not involved in the voluntary consumption of all, but only of some drugs/chemicals of abuse. Recognition of these drug...

...Hassan El-Kashef The effect and mechanism of action of serotonin (5-HT) were studied in the pulmonary circulation of normal and diabetic rabbits. 5-HT (10, 50 and 100 nmol/l) produced a concentration-dependent increase in rabbit pulmonary arterial tension. Pulmonary arterial rings from diabetic...

...Jane E. Smith; Joan M. Lakoski The pharmacological effects of the dual serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine reuptake inhibitor, duloxetine, on serotonergic function in the aging hippocampus were studied using an in vivo chloral hydrate-anesthetized preparation in the female...

... were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity. 4 02 1997 16 04 1997 10 6 2008 Serotonin Corticosterone...

...L.-A. Pini; G. Vitale; M. Sandrini Acetylsalicylic acid (ASA), 400 mg/kg i.p., displayed antinociceptive activity in both the hot-plate and the formalin test. ASA significantly increased brain serotonin (5-HT) content and reduced the number of 5-HT 2 receptors in cortical brain membranes 30 min...