...U. Mengs; R.L. Rudolph Male guinea pigs were treated with senna pods, sennosides, danthron or bisacodyl by gastric intubation for 14 consecutive days. The animals were then killed and the intestine was evaluated by light and electron-microscopic techniques. Macroscopically, the mucosa of the cecum...

...Kan Yang; Kunhua Fan; Ulrich Mengs; Martin Lipkin The cytochemical effects of laxatives on rat colonic epithelial cells were studied. A total of 32 rats was divided into four groups. Three groups were treated with bisacodyl, picosulfate and sennosides for 12 weeks, and a fourth group served...

... the short- and long-term effect of sennosides, bisacodyl, sodium picosulfate and lactulose on epithelial cell proliferation in the ileum and large intestine. Cell proliferation was examined by the BrdUrd labelling technique after 2, 6 and 12 weeks of continuous treatment. Studies in control animals show...

... and gastrointestinal, liver, kidney or adrenal tumors in the rat. 11 6 2008 Laxative Sennosides Carcinogenicity Rat Intestine Pharmacology 1993;47(suppl 1):209 215 A. Lyden-Sokolowski A. Nilsson P. Sjoberg Medical Products Agency, Division of Pharmacology and Toxicology, Uppsala, Sweden Two-Year...

...C.-P. Siegers; J. Siemers; G. Baretton In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes...

...Jean Fioramonti; Chantal Dupuy; Lionel Buéno Ceco-colonic myoelectrical activity was investigated in rats pretreated for 23 weeks by sennosides (10 or 40 mg/kg/day), Na-picosulfate (2.5 or 10 mg/kg/day) or laxative vehicle (control). On the last week of treatment the animals were equipped...

...Elke Leng-Pescklow; K.P. Odenthal; W. Voderholzer; S. Müller-Lissner Rats were treated with sennosides (6 × 10, 6 × 40 or 2 × 30 mg/kg weekly) or with danthron (6 × 500 mg/kg weekly) for 6 months. The laxative effect as measured by faecal wet weight during the first 10 h after treatment increased 3...

...E. Beubler; A. Schirgi-Degen The aim of this study was to investigate whether 5-hydroxy-tryptamine (serotonin, 5-HT) is involved in the mediation of sennoside-induced colonic fluid secretion and diarrhea. Oral administration of purified sennosides (25, 40 and 64 mg/kg) dose-dependently reversed net...

...K.P. Odenthal; E. Leng-Peschlow; W. Voderholzer; S. Müller-Lissner Colonic motility of rats chronically pretreated with either 10 or 40 mg sennosides/kg body weight daily, 30 mg sennosides/ kg twice a week or 500 mg danthron/kg daily for 6 months has been evaluated in ex vivo preparations...

... or a dianthrone. So far, detailed information concerning their metabolism and pharmacokinetic characteristics is available only in a few cases. The best characterized compounds are sennoside, a dianthrone O-glycoside present in senna leaves and senna pods, and its aglycone (rhein anthrone). After oral...

...Elke Leng-Peschlow The effect of oral treatment with sennosides (50 mg/kg) on the time-course of net H 2 O and electrolyte transport rates was studied in 1-hour incubation experiments in the rat colon in vivo. Net H 2 0, Na + and Cl- absorption rates did not change during the first 4 h after...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Senna Anthranoids Sennosides Rhein Aloe...

...Elke Leng-Peschlow Oral and intracecal administration of bisacodyl or sennosides A + B (10–100 mg/kg each) to rats induced a similar quantity of soft feces within 24 h and a similar acceleration of large intestinal transit time, but in each case bisacodyl had a prolonged action. Net fluid...

...K.P. Odenthal; D. Ziegler Isolated uterus and colon segments were taken from sennoside-pretreated female rats. They indicate a possible decrease in spontaneous contractility of both organ segments. Addition of rhein-Na, as one of the probable active metabolites of sennosides, into the bath medium...

...P. Dufour; P. Gendre Sennosides and related compounds are presumed to be severe cell poisons after prolonged ingestion. Some histological and ultrastructural studies in animals and man with such laxative misuse have revealed myenteric plexus and colonic epithelium injuries; but others have failed...

...R.L. Rudolph; U. Mengs After gastric administration of daily 100 mg sennosides/kg body weight, no morphological differences could be found between the colon of treated rats and the controls. In particular, no damage to the intramural nerve tissue could be seen under the electron microscope. 5...

...J. Lemli The metabolism of sennosides is discussed in view of the results obtained during the last years. Rhein anthrone is to be considered as the ultimate active form produced by microorganisms in the colon. Several contributions of this senna symposium bring complementary information of utmost...

...E. Beubler; G. Kollar The aim of this study was to investigate whether prostaglandins (PG) are involved in the mediation of sennoside-induced colonic fluid and electrolyte secretion. Oral administration of senna pod extract dose-dependently reversed net absorption of water, sodium and chloride...

...B.D. Cameron; M.W.A. Phillips; C.A. Fenerty A HPLC method was developed to measure rhein, a laxatively active metabolite of sennosides A + B, in milk and plasma. Samples from 2 lactating rhesus monkeys were taken over 48 h after oral administration of sennosides (1 mg kg –1 ). Detectable rhein...

...J. Fioramonti; G. Staumont; R. Garcia-Villar; L. Buéno Oral administration of sennosides (20–30 mg/kg) to fasted dogs has been shown to induce a strong and long-lasting inhibition of myoelectric colon activity which was evident after a delay of 6–10 h corresponding to orocecal transit and colonic...