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Keywords: Senna
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2011) 88 (5-6): 252–259.
Published Online: 13 October 2011
...A. Vitalone; S. Di Giacomo; A. Di Sotto; A. Franchitto; C.L. Mammola; P. Mariani; S. Mastrangelo; G. Mazzanti Background:Cassia angustifolia L. (senna) is traditionally used as a laxative. Its major components are sennosides that are responsible for the laxative effect. Senna is recommended...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 172–177.
Published Online: 19 June 2009
...U. Mengs; R.L. Rudolph Male guinea pigs were treated with senna pods, sennosides, danthron or bisacodyl by gastric intubation for 14 consecutive days. The animals were then killed and the intestine was evaluated by light and electron-microscopic techniques. Macroscopically, the mucosa of the cecum...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 242–248.
Published Online: 11 June 2008
...K. Ewe; B. Ueberschaer; A.G. Press Retarded colonic transit and disturbed defecation are the most prominent pathophysiological mechanisms in constipation. Both may be influenced by bulking agents and by laxatives such as senna. Direct measurements of the influence of such substances on colonic...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 58–63.
Published Online: 11 June 2008
...Francesco Capasso; Angelo A. Izzo; Nicola Mascolo; Giuseppina Autore; Giulia Di Carlo The effect of in vivo treatment with senna was examined on the ex vivo formation of platelet-activating factor (PAF) by small and large intestine of rat, mouse and guinea pig. A single or a prolonged oral...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 98–109.
Published Online: 11 June 2008
...Wolf Grimminger; Klaus Witthohn Toxicological studies indicate that two hydroxyanthraquinones (HAs), aloe-emodin and emodin, present as minor components in senna, might represent a genotoxic or cancerogenetic risk for man. Since aloe-emodin and emodin occur in senna in the free form as well...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 178–186.
Published Online: 11 June 2008
...A. Heidemann; H.G. Miltenburger; U. Mengs Genotoxicity tests were performed by several laboratories with the drug fructus sennae, senna extract, sennosides, rhein and aloe-emodin. The drug fructus sennae, the sennosides and rhein did not increase mutation frequencies in the following test systems...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 2–6.
Published Online: 11 June 2008
...G. Franz Senna consists of the dried leaflets or fruits of Cassia senna (C. acutifolia) known in commerce as Alexandrian senna and of Cassia angustifolia commonly known as Tinnevelly senna. The senna plants are small shrubs of Leguminosae cultivated either in Somalia, the Arabian peninsula and near...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 31–39.
Published Online: 05 June 2008
.... Senna Laxative Loperamide Cat Colon Motility Myoelectric activity Spike bursts Motor pattern Transit time Pharmacology 36: suppl. 1, pp. 31 -39 (1988) © 1988 S. Karger AG. Basel 0031-7012/88/0367-0031S2.75/0 Effect of Sennosides on Colon Motility in Cats Martin Wienbecka, Ekkehard...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 212–220.
Published Online: 05 June 2008
...P. Faber; A. Strenge-Hesse The excretion of rhein, a laxatively active metabolite of sennosides, was investigated in 100 breast milk samples of 20 post-partum women after intake of a standardized senna laxative (Agiolax), which also contains seeds of Plantago ovata as bulk substances. After daily...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 92–97.
Published Online: 05 June 2008
...Nicola Mascolo; Rosaria Meli; Giuseppina Autore; Francesco Capasso The laxation induced by senna is not modified in rats either maintained on a diet deficient in essential fatty acids (EFAD) or exposed to cold (6 °C) or with yeast-induced fever. In light of our findings it appears conceivable...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 3–6.
Published Online: 05 June 2008
...J. Lemli Senna was introduced in therapy in the 9th century by the Arabs. In the second half of the 19th century chemical investigation of the drug was undertaken, but only a century later the sennosides were isolated.bPharmacological research on senna started at the beginning of this century...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 230–236.
Published Online: 05 June 2008
...Edmund W. Godding Laxatives are classified according to their actions on the gut, and the special role and use of senna in the treatment of constipation are discussed. Standardised senna is the most physiological of all the non-fibre laxatives and is safe when used in appropriate dosage avoiding...