... of the study is to elucidate if there are direct interactions of riluzole and phenobarbital with AMPA-type receptor channels and to determinethe molecular pharmacological mechanisms. Methods: The patch-clamp technique was used combining an ultrafast solution exchange system to investigate the interaction...

...Chung-Ren Jan; Yih-Chau Lu; Bang-Ping Jiann; Hong-Tai Chang; Jong-Khing Huang In human osteosarcoma MG63 cells, the effect of the neuroprotective drug riluzole on the intracellular Ca 2+ concentration ([Ca 2+ ] i ) was measured using fura-2. Riluzole (50–500 µmol/l) caused a rapid and sustained...