... drug (DMARD)-naive patients with rheumatoid arthritis (RA). Objectives: This study aimed to assess the relative remission and LDA rates of tofacitinib, baricitinib, upadacitinib, and filgotinib compared to those of methotrexate (MTX) in DMARD-naive patients with RA. Method: We conducted Bayesian...

...Ruqayyah J. Almizraq; Kayluz Frias Boligan; Bonnie J.B. Lewis; Selena Cen; Heather Whetstone; Rolf Spirig; Fabian Käsermann; Ian K. Campbell; Stephan von Gunten; Donald R. Branch Introduction: Neutrophils are a pivotal cell type in the K/BxN mouse model of rheumatoid arthritis and play an essential...

...Bonnie J.B. Lewis; Donald R. Branch Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation, swelling, and pain in the joints and involves systemic complications. Mouse models of RA have been extensively used to model the pathogenesis of RA and to develop...

... effect of rutin against the rheumatoid arthritis involved via suppression of NF-κB p65 protein expression. The elderly individuals are mostly affected with arthritis, which is also known as the problem in joint movement that affects the overall mobility of the patients [ 1,2 ]. It is basically termed...

...Marie Fechtenbaum; Pauline Lasselin-Boyard; Sarah Salomon; Germain Jelin; Florence Millot; Franck Grados; Patrice Fardellone; Vincent Goëb Background: The efficacy and safety of tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) are well demonstrated. Doses of 4 and 8 mg/kg are used...

...Yasmin Moustafa Ahmed; Basim A.S. Messiha; Ali Ahmed Abo-Saif Background/Aims: Rheumatoid arthritis (RA) is a disabling autoimmune disease for which most current treatments cause massive complications, thereby limiting treatment dose and duration. The anti-arthritic effects of the 3-hydroxy-3...

... Glycosaminoglycans Osteoarthritis Rheumatoid arthritis Chondroitin sulfate (CS) is an orally administered symptomatic slow-acting drug for the treatment of osteoarthritis (OA) able to provide pain relief and increased mobility in OA patients [ 1,2,3 ]. Moreover, CS alone or in combination with glucosamine...

... kinase Rheumatoid arthritis Arthritis Inflammation Diarylpyrazole SD0006 Original Paper Pharmacology 2009;84:42 60 DOI: 10.1159/000227286 Received: December 16, 2008 Accepted: April 27, 2009 Published online: July 4, 2009 SD0006: A Potent, Selective and Orally Available Inhibitor of p38 Kinase...

... joint disease Infliximab Myeloperoxidase Oxidative stress Rheumatoid arthritis Original Paper Pharmacology 2009;83:211 216 DOI: 10.1159/000200022 Received: August 28, 2008 Accepted after revision: November 12, 2008 Published online: February 7, 2009 Infliximab Reduces Myeloperoxidase...

...S.P. Venkateshan; S. Sidhu; S. Malhotra; P. Pandhi Rheumatoid arthritis (RA) is a chronic multisystem disease. A characteristic feature of RA is persistent inflammatory synovitis, usually involving the peripheral joints in a symmetric distribution. The prevalence of RA is approximately 0.8...

...E. Beccerica; G. Piergiacomi; G. Curatol; G. Ferretti We have demonstrated significant differences in 1,6-diphenyl-1,3,5-hexatriene fluorescence polarization values between lymphocyte membranes of untreated rheumatoid arthritis patients and lymphocyte membranes of patients treated...

...R.P. Sharma; J. Smillie; D.G. Palmer The concentrations of gold in whole blood, serum, urine and blood cells of patients with rheumatoid arthritis were measured during 6 months of oral treatment either with Auranofin or placebo. Any adverse effects attributable to the treatments were also recorded...

.... An inhibitory effect on hyaluronate production by indomethacin was inconstant. In no case indomethacin depressed cell proliferation. There were no differences in the drug response of the cells whether they were derived from patients with rheumatoid arthritis or nonrheumatoid articular diseases. 28 08 1970...