... levels were reported in inflammatory respiratory diseases such as asthma, chronic obstructive pulmonary disease, and pulmonary hypertension. H 2 S donors or drugs that increase H 2 S have emerged as novel treatments for inflammatory respiratory diseases. We previously showed that resveratrol (RVT) causes...

..., the functional role of SIRT1 in pressure overload-induced cardiac hypertrophy and dysfunction remains unclear. Resveratrol (Rsv), a widely used activator of SIRT1, has been reported to protect against cardiovascular disease. We here examine whether activation of SIRT1 by Rsv attenuate pressure overload-induced...

...Suliman Al Humayed; Fahaid Al-Hashem; Mohamed A. Haidara; Abbas O. El Karib; Samaa S. Kamar; Shaimaa N. Amin; Bahjat Al-Ani Background: The potential protective effects of resveratrol (RES) on the modulation of hepatic biomarkers of apoptosis and survival, p53-Bax axis, and B-cell lymphoma 2 (Bcl-2...

...Guoyong Liu; Qiang Wang; Yan Shi; Xiaofei Peng; Hong Liu; Youming Peng; Liyu He Background/Aim: Focal segmental glomerulosclerosis (FSGS) typically presents with nephrotic range proteinuria, which could eventually develop into end-stage renal disease. Resveratrol (RSV) is a natural polyphenol...

...Hui Yang; Ye Yuan; Cheng Luo; Haixia He; Yuanda Zhou While anti-tumor activity of resveratrol has been demonstrated for many cancers, little is known about its effects on soft tissue sarcoma. Overexpression of TGF-β1, a protein inhibited by resveratrol, is a well-known feature...

...Hyun Dong Je; Myeong Hwan Lee; Ji Hoon Jeong; Sun Young Park; Uy Dong Sohn The present study was undertaken to investigate the influence of resveratrol on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric...

...Nicole Sabolovic; Tony Heurtaux; Anne-Claude Humbert; Stéphanie Krisa; Jacques Magdalou Background/Aims: Glucuronidation of cis - and trans -resveratrol (3,5,4’-trihydroxy-trans-stilbene), which is a naturally occurring phytoalexin known to exert a number of beneficial health effects...

...Moussa Alkhalaf Background and Purpose: Trans -resveratrol (RSVL; 3,4′,5-trihydroxystilbene), a natural compound found in grapes, berries, peanuts and red wine exerts certain anticancer roles in different human cancer types. However, the exact molecular mechanism(s) behind such a role remains...

... radical generation. The present study was aimed at evaluating the effects of trans-resveratrol in the prevention of colchicine-induced cognitive impairment and oxidative stress in rats. Intracerebroventricular administration of colchicine (15 µg/5 µl) induced impaired cognitive functions in both...

...Hale Toklu; Inci Alican; Feriha Ercan; Goksel Sener Objective: The present study aimed to investigate the possible beneficial activities of resveratrol (3,5,4′-trans-trihydroxystilbene), a natural phytoalexin, on contractility and oxidant damage after ischemia/reperfusion (I/R) of the rat urinary...

... is involved in the etiology of diabetic nephropathy. Resveratrol, a polyphenolic phytoalexin present in red wine, is known to possess potent antioxidant properties and thus we aimed to examine its effect on renal function and oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced...

...Y.K. Gupta; Geeta Chaudhary; Ajay K. Srivastava The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats. Resveratrol (20, 40, and 80 mg/kg i.p.) administered 20 min prior...