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Keywords: Rats
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Pharmacology
Pharmacology (2020) 105 (9-10): 561–567.
Published Online: 26 February 2020
... is also implicated in the generation of the SWDs. Objective: This study investigated the effects of systemic and local administrations of U-92032 into the brain of Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Methods: GAERS animals underwent stereotaxic surgery for the placement of EEG recording...
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Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (3-4): 201–207.
Published Online: 18 July 2017
... examined the antinociceptive effects of isosakuranetin, a plant-derived transient receptor potential melastatin 3 blocker, in a rat model of peripheral neuropathy. Adult male Sprague-Dawley rats were first allowed to go through the chronic constriction injury surgery to develop neuropathic pain. They were...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 99 (5-6): 236–239.
Published Online: 02 February 2017
... on the disposition of lithium in rats. Methods: Pharmacokinetic experiments with lithium were performed. Results: Until 60 min after the intravenous administration of lithium chloride at 30 mg/kg as a bolus, 17.8% of lithium injected was recovered into the urine. Its renal clearance was calculated to be 1.62 mL/min...
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2016) 97 (5-6): 224–232.
Published Online: 13 February 2016
... induced by LPS in rats. Methods: Rats received a single injection of LPS (5 mg/kg, i.v.). Naringenin was given for 4 consecutive days, at 2 doses (50 and 100 mg/kg/day, p.o.), starting 3 days before LPS administration. Results: LPS significantly increased wet/dry lung weight ratio, malondialdehyde, nitric...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2015) 96 (5-6): 210–216.
Published Online: 01 September 2015
... been investigated in rats with unilateral hindlimb ischemia. For 28 days, cilostazol and L -carnitine were administrated separately or as a combination. The distance walked before gait disturbance developed was measured using a treadmill for 5 days a week. The capillary density of the ischemic hindlimb...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2015) 96 (3-4): 112–117.
Published Online: 18 July 2015
... of thymoquinone (TQ) on GEN-induced acute renal failure (ARF). Methods: The rats were divided into 6 groups: sham group, control group, GEN-treated group and the TQ-treated groups. At the end of the research period, the serum blood urea nitrogen (BUN) and creatinine (Cr) were measured. The kidneys were...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 93 (3-4): 113–119.
Published Online: 26 February 2014
... nociceptive stimulus - the tail flick test [ 8 ]. Randall-Selitto Test For mechanical stimulation, a progressively increased pressure was applied to the dorsal surface of the rat's paw using an analgesimeter (Ugo-Basile, Italy). The instrument increased force on the paw at a rate of 32 g/s...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 93 (1-2): 4–9.
Published Online: 21 December 2013
... with the sham group. Figure 1 shows that glutamate concentrations were higher in the MK801 and DHK groups and lower in the GBP group than in the IR group (p < 0.01). Fig. 1 Serum glutamate increased in rats subjected to myocardial IR in vivo . a p < 0.01 versus sham; b p < 0.01 versus IR...
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2010) 85 (1): 48–53.
Published Online: 19 December 2009
.... Experiments were conducted on normotensive Wistar Kyoto rats. The pain threshold was measured using an analgesimeter. It was concluded that the single administration of an antidepressant increases the analgesic action of fentanyl. Four-day premedication with fluoxetine and reboxetine significantly attenuated...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (4): 234–239.
Published Online: 17 September 2009
... of the γ-aminobutyric acid type A receptor complex. The aim of this study was to determine the effects of ifenprodil on the behavioral and electroencephalographic (EEG) manifestations of seizures in lindane-treated rats. Adult male Wistar rats with three electrodes implanted into the skull were treated...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2008) 82 (3): 180–186.
Published Online: 14 August 2008
... neuropathy are discussed. Diabetes Hyperalgesia Streptozotocin Magnesium ions Morphine Fentanyl Buprenorphine Rats © 2008 S. Karger AG, Basel 2008 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (6): 344–350.
Published Online: 10 June 2008
...Hemendra N. Bhargava; George A. Matwyshyn The effect of dizocilpine (MK-801), an N-methyl- D -aspartate receptor antagonist, on the development of tolerance to the analgesic and hyperthermic effects of morphine was determined in the rat. Tolerance to morphine in male Sprague-Dawley rats was induced...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (3): 168–174.
Published Online: 10 June 2008
... Swiss Webster mice and male Sprague-Dawley rats. In mice, high activity of NOS was found in cerebellum, hypothalamus and midbrain; intermediate activity in pons-medulla, hippocampus, amygdala, corpus striatum and cortex; and low activity in the spinal cord. In rat, highest activity of NOS was observed...