... is also implicated in the generation of the SWDs. Objective: This study investigated the effects of systemic and local administrations of U-92032 into the brain of Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Methods: GAERS animals underwent stereotaxic surgery for the placement of EEG recording...

... with osteoarthritis. Puerarin has multiple effects including restoring mitochondrial function. In this study, the potential effects of puerarin on osteoarthritis and osteoarthritis associated mitochondrial dysfunctions were evaluated. Methods: Osteoarthritis rats were treated with puerarin and the severity...

...Adel Galal El-Shemi; Osama Adnan Kensara; Aiman Alsaegh; Mohammed Hasan Mukhtar Aims: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying mechanisms. Methods: Diabetes was induced...

... examined the antinociceptive effects of isosakuranetin, a plant-derived transient receptor potential melastatin 3 blocker, in a rat model of peripheral neuropathy. Adult male Sprague-Dawley rats were first allowed to go through the chronic constriction injury surgery to develop neuropathic pain. They were...

... on the disposition of lithium in rats. Methods: Pharmacokinetic experiments with lithium were performed. Results: Until 60 min after the intravenous administration of lithium chloride at 30 mg/kg as a bolus, 17.8% of lithium injected was recovered into the urine. Its renal clearance was calculated to be 1.62 mL/min...

...Mohamed Elsayed Kelany; Tahir M. Hakami; Adel H. Omar; Mohamed A. Abdallah Aims: The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. Methods: Diabetes was induced in 32 adult male albino...

... induced by LPS in rats. Methods: Rats received a single injection of LPS (5 mg/kg, i.v.). Naringenin was given for 4 consecutive days, at 2 doses (50 and 100 mg/kg/day, p.o.), starting 3 days before LPS administration. Results: LPS significantly increased wet/dry lung weight ratio, malondialdehyde, nitric...

... been investigated in rats with unilateral hindlimb ischemia. For 28 days, cilostazol and L -carnitine were administrated separately or as a combination. The distance walked before gait disturbance developed was measured using a treadmill for 5 days a week. The capillary density of the ischemic hindlimb...

... of thymoquinone (TQ) on GEN-induced acute renal failure (ARF). Methods: The rats were divided into 6 groups: sham group, control group, GEN-treated group and the TQ-treated groups. At the end of the research period, the serum blood urea nitrogen (BUN) and creatinine (Cr) were measured. The kidneys were...

... was to assess the possible ameliorative effect of mesenchymal stem cells (MSCs) in comparison to gabapentin on pentylenetetrazole (PTZ)-induced epileptogenesis and its consequences. Methods: Thirty-two rats were divided into 4 equal groups; group I: saline-injected group, group II: PTZ group, which received 13...

.... Analgesia Diabetes Magnesium ions N-methyl- D -aspartate receptor Morphine Rats The last 20 years have brought substantial progress in the treatment of many diseases, previously intractable by conventional therapy. In contrast, relief of neuropathic pain is still an unsatisfactorily resolved...

.... Glutamate Ischemia-reperfusion injury Ventricular arrhythmia Rats Glutamate is an important excitatory neurotransmitter in the central nervous system. Glutamate can overactivate its ionotropic receptors (ligand-gated channels) and induce Ca 2+ entry to promote Ca 2+ overload in cultured...

... hypertensive rats, in comparison to those of spironolactone (SPI). Uninephrectomized rats, given 1% NaCl to drink, were infused with aldosterone (0.75 µg/h, s.c.). In experiment 1, SM-368229 (10, 30 mg/kg) or SPI (100 mg/kg) were administered for 14 days immediately after aldosterone/salt loading...

...Oliver Mauric; Christiane Thallinger; Sylvia A. Kugler; Samir M. Joukhadar; Florian M. Kovar; Karl H. Konz; Wolfgang Graninger; Christian Joukhadar Background/Aims: We measured the extracellular concentrations of fluconazole in lung tissue of septic and healthy rats. Methods: A single intravenous...

.... Experiments were conducted on normotensive Wistar Kyoto rats. The pain threshold was measured using an analgesimeter. It was concluded that the single administration of an antidepressant increases the analgesic action of fentanyl. Four-day premedication with fluoxetine and reboxetine significantly attenuated...

... of the γ-aminobutyric acid type A receptor complex. The aim of this study was to determine the effects of ifenprodil on the behavioral and electroencephalographic (EEG) manifestations of seizures in lindane-treated rats. Adult male Wistar rats with three electrodes implanted into the skull were treated...

... Phortress indicate organ sites of potential toxicity. CYP1A1 protein was induced transiently in the lungs of both species and in the livers of rats. Elimination of hepatic DNA adducts and rat pulmonary adducts was evident; however, murine pulmonary adducts persisted. Conclusion: Rodent preclinical...

... Helena Makulska-Nowak Stanis aw Witold Gumu ka Department of Pharmacodynamics, Medical University of Warsaw, Warsaw, Poland Key Words Diabetes Hyperalgesia Streptozotocin Magnesium ions Morphine Fentanyl Buprenorphine Rats Abstract Streptozotocin-induced hyperglycemia accompanied...

... Swiss Webster mice and male Sprague-Dawley rats. In mice, high activity of NOS was found in cerebellum, hypothalamus and midbrain; intermediate activity in pons-medulla, hippocampus, amygdala, corpus striatum and cortex; and low activity in the spinal cord. In rat, highest activity of NOS was observed...

...Hiroshi Watanabe; Marline Clozel; Jean-Paul Clozel The purpose of this study was to determine the effects of nimodipine, a calcium antagonist, on regional cerebral blood flow (CBF) in experimental subarachnoid hemorrhage (SAH) rats. Regional CBF was measured by the radioactive microspheres method...