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Keywords: Rat liver microsomes
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (5-6): 301–307.
Published Online: 19 August 2017
... ]. The active metabolite 4'-hydroxyphenyl carvedilol may contribute to carvedilol clinical effects, being 13 times more potent than carvedilol for the beta-blocking effect [ 7 ]. Carvedilol Citalopram Pharmacokinetics Cytochrome P450 Preclinical study Rat liver microsomes Enzyme inhibition ©...
Journal Articles
Pharmacology (2015) 95 (3-4): 133–138.
Published Online: 25 March 2015
... was to investigate the possible interaction of losartan and glimepiride both in vitro (rat liver microsomes) and in vivo (healthy Sprague-Dawley rats). Methods: In rat liver microsomes, 1-10 μmol/l losartan and glimepiride were coincubated, and the inhibitory effect was analyzed. In the subsequent pharmacokinetic...
Journal Articles
Journal Articles