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Keywords: Rat
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Pharmacology (2021) 106 (7-8): 446–450.
Published Online: 12 May 2021
...Yuichi Uwai; Tomohiro Nabekura Lithium, administered to patients of bipolar disorders, is mainly excreted into urine, and tubular reabsorption at the proximal tubule is involved in the renal handling of lithium. In this study, we examined the renal excretion of lithium in rats with Fanconi syndrome...
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Pharmacology
Pharmacology (2021) 106 (1-2): 106–113.
Published Online: 26 October 2020
... applications cannabinoids agonist JWH-133 in uterine IR damage and, hence, in the transplant process. Methods: Rats were divided into 4 groups ( n = 8), performed uterine IR, and treated 2 groups with JWH-133. After anesthesia, ischemia was applied for 1 h to the uterus while reperfusion was applied for 3 h...
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Pharmacology
Pharmacology (2017) 100 (3-4): 194–200.
Published Online: 21 July 2017
.... We applied serum metabonomics and Fisher discrimination for the early diagnosis of its toxic reaction in order to help diagnose these toxicities. Methods: A total of 45 rats were randomly divided into Control group, Aspirin group, and Ibuprofen groups. The experiment groups were given intragastric...
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Pharmacology
Pharmacology (2015) 96 (5-6): 217–225.
Published Online: 09 September 2015
...-metylglutary-CoA reductase inhibitor, simvastatin, and the natural flavonoid, hesperidin, were investigated against complete Freund's adjuvant-induced RA in rats. Methods: A normal control group, an arthritis control group, 2 reference treatment groups receiving dexamethasone (1.5 mg/kg/day) and methotrexate...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2015) 96 (3-4): 167–174.
Published Online: 12 August 2015
... of cinnarizine against experimentally induced bronchial asthma. Methods: Bronchial asthma was induced by ovalbumin sensitization and challenge. Rats were allocated into a normal control, an asthma control, a dexamethasone (standard) treatment, and 2 cinnarizine treatment groups. The respiratory functions tidal...
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Subject Area:
Pharmacology
Pharmacology (2015) 95 (3-4): 160–165.
Published Online: 03 April 2015
... pharmacokinetic interactions in simultaneous oral administration of SAHA and lapatinib to rats. Methods: Twenty-four rats were divided randomly into 3 groups: a lapatinib group (lapatinib 25 mg/kg, n = 8), a SAHA group (SAHA 25 mg/kg, n = 8), and a coadministration group (SAHA 25 mg/kg and lapatinib 25 mg/kg, n...
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Subject Area:
Pharmacology
Pharmacology (2014) 94 (3-4): 170–178.
Published Online: 22 October 2014
... with a promising in vitro activity, was investigated. Methods: The quantification of the BPT derivative and the identification of metabolites in the plasma of Wistar rats after i.p. and oral administration of 10 mg/kg were performed by the HPLC-mass spectrometry method. Results: Following a single i.p. dose...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 93 (3-4): 129–136.
Published Online: 13 March 2014
... to evaluate whether nicorandil could induce COX-2 in rats and to elucidate its mode of induction pharmacologically. Methods and Results: Three hours after administration of nicorandil (10 mg/kg, p.o.), COX-2 mRNA and protein were significantly increased in the left ventricle, although other cardioprotective...
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Subject Area:
Pharmacology
Pharmacology (2009) 84 (6): 367–376.
Published Online: 14 November 2009
... expression as well as agonist-induced contraction in rat aorta, and if angiotensin II (Ang II) levels during pregnancy are related to these changes. Female Wistar rats were divided randomly into nonpregnant (NP) and pregnant groups (first week: P1, second week: P2, third week: P3). Subsets of animals were...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (5): 257–263.
Published Online: 24 September 2009
.... In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-α and intercellular adhesion molecule-1 (ICAM-1...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (2): 104–110.
Published Online: 29 July 2009
...: Baclofen was tested in 2 doses (1 and 5 mg/kg) in 3 age groups (postnatal days 7, 16 and 21) in order to assess its effect on acute nociception and motor co ordination in rat pups. Pain was evaluated by measurement of paw/tail withdrawal latencies, and motor coordination by age-relevant tests. Results...