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Keywords: Pyrazinoylguanidine
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Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1996) 52 (3): 135–144.
Published Online: 10 June 2008
...Yousif I. A-Rahim; Karl H. Beyer Jr.; Elliot S. Vesell Pyrazinoylguanidine (PZG) is a new antihyperglycemic, antihyperlipidemic drug. The current study reports on the development of an animal model in which the favorable metabolic effects of PZG, previously described in diabetic patients, could...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1996) 53 (4): 197–210.
Published Online: 10 June 2008
...Yousif I. A-Rahim; Karl H. Beyer Jr.; Elliot S. Vesell The effects of pyrazinoylguanidine (PZG) on lipolysis and intracellular cyclic AMP concentrations were investigated in isolated rat adipocytes. PZG reduced basal cyclic AMP concentrations and blocked in a concentration-dependent manner...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1997) 54 (5): 256–260.
Published Online: 10 June 2008
...Mark H. Follansbee; Karl H. Beyer, Jr.; Elliot.S. Vesell This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate cataract development in streptozotocin (STZ)-induced diabetic rats. After a single, intraperitoneal dose of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1992) 44 (3): 124–138.
Published Online: 06 June 2008
...Karl H. Beyer, Jr.; Thomas Gelarden; Elliot Vesell In addition to glomerular filtration and passive back diffusion of urea, there occurs across the renal tubule bidirectional transport of urea inhibitable in one or both directions by specific analogs of pyrazinoylguanidine (PZG). Effect of PZG...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1999) 58 (3): 140–146.
Published Online: 05 February 1999
...Elliot S. Vesell; Karl H. Beyer Jr. In a three-phase study, single oral doses of placebo, followed in 1 week by pyrazinoylguanidine (PZG; 900 mg), followed in 3 weeks by pyrazinoic acid (PZA; 300 mg) were given to 8 normal male subjects. Blood analyses performed 0, 2 and 4 h after administration...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1998) 57 (2): 96–103.
Published Online: 29 July 1998
.... The present placebo-controlled study evaluated prospectively lipid-lowering effects of pyrazinoylguanidine (PZG) in 6 ESRD patients undergoing maintenance hemodialysis. The design of the study entailed a placebo phase of 1 week followed by 3 weeks of PZG, 400 mg three times a day. Compared to placebo, PZG...