...Ivan Krečak; Ljerka Pivac; Hrvoje Holik; Martina Morić Perić; Ivan Zekanović; Eva Čubrić; Marko Skelin; Marko Lucijanić Introduction: Proton pump inhibitors (PPIs) are known to decrease the risk of gastrointestinal (GI) bleeding. However, concerns have been raised regarding the potential...

... of these mediators are antioxidants, whose loss may predispose to oxidative stress, which is believed to be the main aggravator of several diseases including peptic ulcer. Proton pump inhibitors (PPIs) are drugs that are highly effective and widely used for therapeutic management of peptic disorders through...

...Ali Sigaroudi; Christoph Stelzer; Tina Braun; Sebastian Frechen; Sven Hüttner; Michael Schröter; Martina Kinzig; Uwe Fuhr; Ulrike Holzgrabe; Fritz Sörgel Background: Pantoprazole is a proton pump inhibitor drug mainly used for treating peptic diseases. Adverse effects of pantoprazole...

... on the discovery and development of proton pump inhibitors (PPIs) of stomach acid production. This class of drugs approaches the ideal and exemplifies successful application of modern pharmacological principles to drug discovery and development. Moreover, the use of PPIs as a pharmacological tool allowed...

...W. Kromer; U. Krüger; R. Huber; M. Hartmann; V.W. Steinijans Gastric proton pump inhibitors (PPIs) are substituted benzimidazole prodrugs that require an acid-induced activation. Its rate depends on the reactivity of the molecule relative to the environmental pH and determines the drug’s tissue...