... agonist B-HT 920 in the pithed rat preparation. Administration of nifedipine or staurosporine significantly reduced the diastolic blood pressure of pithed rats. Staurosporine displaced the dose-diastolic pressure response curves for B-HT 920 and St587 to the right in a dose-dependent manner. The ED 50...

...Dariusz Pawlak; Barbara Malinowska; Wlodzimierz Buczko The influence of acetaldehyde (30 mg/kg i.v.) on blood pressure and heart rate in anesthetized and pithed rats was studied. In anesthetized rats we observed a small increase, and a subsequent considerable decrease in mean blood pressure...

... in the pithed rat using two chemical classes of α-adrenoceptor agonists, the phenethylamines and imidazolines, in order to determine if they utilize different signal transduction mechanisms. Pertussis toxin pre-treatment (50 µg/kg, i.v., 3 days prior to experimentation) slightly inhibited the pressor response...

...Barbara Malinowska; Dariusz Pawlak; Ewa Chabielska; Włodzimierz Buczko In pithed rats, the intravenous administration of serotonin (3, 10, 30, 100, 300 and 1,000 µg/kg) produced a dose-dependent increase in blood pressure. This action of 5-HT was not changed by chronic ethanol intoxication (6.0 g...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pithed rats Mean arterial blood pressure Dihydroergotamine 5-Hydroxytryptamine Noradrenaline Cyproheptadine Pizotifen...

...Barbara Malinowska; Włodzimierz Buczko In pithed rats intravenous administration of serotonin (5.0, 10.0, 20.0, 30.0 and 50.0 μg/kg) produced a dose-dependent increase in blood pressure. The pressor response to serotonin was significantly reduced by captopril (1.0, 5.0 and 50.0 mg/kg) in a dose...