... by greatly enhancing relaxations in wild-type mice, while having no effect in Gper -/- mice. Contractions to angiotensin II and phenylephrine in wild-type mice were partly sensitive to gp91ds-tat but unaffected by aging. Again, deletion of GPER abolished effects of Nox inhibition on contractile responses...

... the role of oestrogen as a mediator of the contractile function of α 1 -adrenergic receptors. Rats underwent ovariectomy (OVX) or were sham-operated, and the OVX rats were treated with vehicle (corn oil) or 17β-oestradiol (E 2 ) for 5 days either 10, 28 or 60 days after OVX. The OVX increased phenylephrine...

... were less sensitive to phenylephrine and KC1 when the data were expressed in absolute values or as percentages of the maximum responses. Sensitivity and reactivity in strips from hyperthyroid rats were similar to those observed in control strips. Renal vasculature obtained from hypothyroid rats also...

...Melvin J. Fregly; Margarethe Brummermann Chronic exposure of rats to cold (5°C, 3-4 weeks) results in the development of hypertension. To assess potential mechanisms by which this may occur, the vascular responsiveness to administration of phenylephrine (an α-adrenergic agonist) and angiotensin II...

...Suleiman I. Sharif The contractile effect of dopamine in the rat isolated seminal vesicle was investigated to determine the nature of the receptors involved. Noradrenaline (NA; 10 –8 to 10 –4 mol/l), phenylephrine (PE; 10 –7 to 10 –4 mol/l > and dopamine (DA; 10 –5 to 10 –2 mol/l) produced...

... decreased HR (accompanied by prolonged RR and PP) and Pa but increased Wd, Pd, SYa, DNa, Dw, dp, mp, Ra and Ta; (5) phenylephrine decreased HR (accompanied by prolonged RR and PP) and Pa but increased Wd, Dd, DNa, mp and Ra; (6) phentolamine decreased SYa, DNa, DWa, Dw, dp and mp. This study illustrates...

...Debebe Gebremedhin; Mária Z. Koltai; Gábor Pogátsa; Kálmán Magyar; Pál Hadházy The mechanical responses to acetylcholine (ACh), sodium nitroprusside and phenylephrine (PE) were determined in normal and diabetic dog renal arterial strips with and without endothelium. Experimental diabetes increased...

...Emine Demirel; Kazim Türker Phenylephrine tested on the isolated endothelium intact rat aortic strips elicited an enhanced response in the second assay when compared with the response obtained in the first trial. Removal of the endothelium and the pretreatment of the strips in the endothelium...

...Jeremiah T. Herlihy; Peter V. Berardo Concentration-response curves to potassium chloride, phenylephrine, serotonin and calcium chloride were obtained from rat aortic strips subjected to preloads of 0.75, 1.5 or 3.0 g. The sensitivity of the aortic smooth muscle to potassium chloride, phenylephrine...

... was also augmented by other potassium conductance blockers (CsCl and 4-AP). On the other hand, the contractile response to phenylephrine used as a control drug was not affected by the extracellular potassium concentration or by CsCl. Verapamil or removal of extracellular calcium abolished the TEA...

...Bobby W. Sandage, Jr.; Patrick Fletcher Single intraperitoneal doses of phenylephrine (PE), phenylpropanolamine (PPA) and pseudoephedrine (PSD) have differing effects on blood glucose in stressed, normal and goldthioglucose (GTG) mice. PE in normal and GTG mice caused a pronounced but temporary...

... against hypertension reported here is unknown although administration of tyrosine was accompanied by a reduced cardiovascular responsiveness to graded doses of phenylephrine. 5 12 1984 15 01 1985 4 6 2008 © 1985 S. Karger AG, Basel 1985 Copyright / Drug Dosage / Disclaimer...

...R.J. Ress; M.A. Rahmani; M.J. Fregly; F.P. Field; C.M. Williams The vascular reactivity to DL -ortho-, meta-, and para-octopamine was tested in vitro in aortic smooth muscle of the rat. When reactivities were compared on a molar basis with L -phenylephrine, an α-adrenergic agonist, the potencies...

... (LHR). Treatment with L -NAME did not alter the contractile response induced by phenylephrine; however, indomethacin increased the contraction to phenylephrine only in LHR aortae (1.36 ± 0.08 g, n = 6, vs. 1.97 ± 0.09 g, n = 7). Both phenylephrine and caffeine evoked rapid and phasic contractions...

...Carlos R. Tirapelli; Fábio E. Mingatto; Ana M. de Oliveira The purpose of the present study was to investigate the effects of vitamin K 1 on vascular smooth muscle contractility in response to phenylephrine (Phe) during hypoxia. Rat carotid rings were placed in an organ chamber containing Krebs...

...A.M. de Oliveira; C. Campos-Mello; M.C. Leitão; F.M.A. Correa Functional correlates of α 1 -adrenoceptors were studied in thoracic aorta and carotid arteries from Wistar rats, at maturation (3- and 8-week-old) and aging (17- and 29-week-old) phases, using phenylephrine (PHE) and KCl. PHE and KCl...