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Keywords: Phenobarbital
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Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (3): 146–153.
Published Online: 10 June 2008
... carbamate), halothane, and ether. CO 2 anesthesia was used as the control comparator. Theophylline was used as a probe for CYP1A activity, phenobarbital for CYP2B/2C, flecainide for CYP2D1, and ethosuximide for CYP 3A activity. All probes were administered via tail vein injection after anesthetic-induced...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 51 (1): 13–23.
Published Online: 10 June 2008
... not significantly differ (p > 0.05) between the untreated and hGH (2 µg/ml)-treated hepatocytes. However, hGH treatment decreased µ GST activity (p < 0.05), whereas α GST activity was unaltered. As positive controls for our culture system and to corroborate our findings, we examined phenobarbital induction...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 38 (5): 319–326.
Published Online: 05 June 2008
...Tekvani Purshottam; Rajendrakumar Srivastava Rats were injected intraperitoneally with phenobarbital (PB) and 3-methylchol-anthrene (MC) which are microsomal enzyme inducers, and methyl iodide (Mel), cobalt chloride (COCI 2 ) and tri- o -cresyl phosphate (TOCP) which are inhibitors of the enzymes...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1987) 35 (4): 227–233.
Published Online: 05 June 2008
...Tekvani Purshottam; Rajendra K. Srivastava Rats were injected intraperitoneally with phenobarbital (PB) and 3-methylcholanthrene (MC), 80 and 20 mg/kg, respectively, for 3 consecutive days and then administered threshold lethal dose of the organophosphorus insecticide, parathion, 10 mg/kg i.p...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1985) 31 (1): 40–49.
Published Online: 04 June 2008
...Tzuu-Huei Ueng; Alvito P. Alvares Pretreatment of rabbits with phenobarbital caused significant increases in total pulmonary cytochrome P-450 content, benzo(a)pyrene hydroxylase and 7-ethoxycoumarin O-deethylase activities and to a lesser extent in benzphetamine N-demethylase activity in lung...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1985) 31 (5): 284–288.
Published Online: 04 June 2008
...Alan H. Lau; Elizabeth Chow-Tung; Farahnak K. Assadi; Linda Fornell; Eunice John To determine the effect of dialysate osmolarity on peritoneal dialysis drug transfer, peritoneal dialysis clearances of theophylline, phenobarbital, and tobramycin were determined in 10 rabbits using dialysate...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1985) 30 (6): 333–338.
Published Online: 04 June 2008
...Norio Hobara; Akiharu Watanabe; Hideo Nagashima Blood ethanol levels following intravenous ethanol administration were much higher during anesthesia with diethyl ether (ether), phenobarbital and pentobarbital than in unanesthetized control rats. Blood acetaldehyde levels were significantly lower...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1984) 28 (6): 329–335.
Published Online: 04 June 2008
... administration: 46–73 µmol/kg with the minimal value at 6 h. Of the metabolites, phenobarbital was maximally effective at 2 h after administration (ED 50 35 µmol/kg), whereas phenylefhylmalondiamide (PEMA) only had a weak anticonvulsant effect (ED 50 1.55mmol/kg at 2 h). By determination of primidone and its...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1984) 28 (4): 211–215.
Published Online: 04 June 2008
...P.V. Luoma; J.E. Heikkinen; P.R. Ylöstalo The effect of phenobarbital (PB) on serum hormones in late pregnancy was investigated. 18 pregnant women were studied before and after 2 weeks of PB treatment (100 mg per os, daily at 8 p.m.) by measuring serum estradiol, estriol, progesterone, testosterone...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1980) 21 (1): 59–63.
Published Online: 30 May 2008
...Bahjat Abbas-Ali The effect of mercuric chloride (2 mg/kg) on microsomal enzymes in mouse liver was investigated in phenobarbital- and 3-methyicholanthrene-induced hepatic microsomes. The metal caused an increase in total microsomal protein in noninduced controls, whereas no significant changes...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1978) 17 (6): 341–344.
Published Online: 29 May 2008
...Henry K.J. Hahn; Anthony J. Barak; Dean J. Tuma; Michael F. Sorrell Administration of phenobarbital to rats over a period of 5 days was shown to increase hepatic lipid peroxidation concomitant with induction of cytochrome P-450 and cytochrome c reductase. The purpose of this study was to determine...