...Patricia N. Sidharta; Paul L.M. van Giersbergen; Jasper Dingemanse Purpose: To investigate the multiple-dose pharmacokinetics (PK), pharmacodynamics (PD), and tolerability of palosuran, a selective, potent antagonist of the human UT receptor. Methods: This was a double-blind, randomized, placebo...

... + 300 mg bupropion were ingested concomitantly, after a pretreatment regimen with bupropion (7 days). The PK parameters of nebivolol and its active metabolite were analyzed by noncompartmental modeling, while the pharmacodynamic (PD) parameters (blood pressure and heart rate) were assessed at rest...

...Shirin Bruderer; Noémie Hurst; Priska Kaufmann; Jasper Dingemanse Objective: The objective of this study was to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of selexipag, an orally available selective prostacyclin receptor agonist, in development for pulmonary arterial...

... Pharmacodynamics Pharmacokinetics L -Carnitine Mounting evidence suggests that exogenous carnitine and derivatives play an important role in the metabolism of both carbohydrates and lipids and improve insulin resistance [ 1,2,3 ]. Human trials have shown the effectiveness of acetyl- L -carnitine...

... Cetirizine Efficacy H 1 antihistamines Pharmacodynamics Pharmacokinetics Quality of life Safety Somnolence Allergic rhinitis (AR) is a common chronic respiratory disorder characterized by nasal symptoms including sneezing, rhinorrhoea, nasal congestion and nasal itching, often accompanied...

... and infectious diseases. Methods: We investigated the pharmacokinetics (PK) and pharmacodynamics of recombinant human IL-12 (rhIL-12) and rhIL-12 combined with hepatitis B surface antigen (HB s Ag) after administration by subcutaneous (s.c.) injection or intravenous infusion in cynomolgus monkeys. Results: After...

...Fritz Sörgel; Ursula Thyroff-Friesinger; Andrea Vetter; Bernhard Vens-Cappell; Martina Kinzig Aim: To compare the steady-state pharmacokinetics and pharmacodynamics (PK/PD) of two erythropoesis-stimulating agents (ESA), HX575 (Binocrit®, Sandoz GmbH, Holzkirchen, Germany), human recombinant epoetin...

... College of Medicine, Hershey, Pa., and Life Sciences Greenhouse of Central Pennsylvania, Harrisburg, Pa., USA Key Words Drug Pharmacodynamics Pharmacokinetics Polydrug use Structure-activity relationships Abstract The advent of functional genomics, proteomics, chemi-informatics, and other systems...

... Pharmacodynamics Pharmacology 1989;39:78-88 Oral 5-Fluorouracil in Psoriasis: Pharmacokinetic-Pharmacodynamic Relationships Darrell R. Abernethy, Joseph C. Alper, Michael C. Wiemann, Charles J. McDonald, Paul Calabresi Divisions of Clinical Pharmacology, Dermatology, and Clinical Oncology, Department...

...Peter Propping; Waltraut Friedl Most of the well-known examples of pharmacogenetics are based on differences of biotransformation and elimination of drugs. Since a drug interacts with a genetically determined biological target, hereditary differences on the pharmacodynamic level are also probable...

.... Caspofungin Micafungin Anidulafungin Pharmacokinetics Pharmacodynamics Echinocandins Review Pharmacology 2006;78:161 177 DOI: 10.1159/000096348 Published online: October 17, 2006 The Echinocandins: Comparison of Their Pharmacokinetics, Pharmacodynamics and Clinical Applications Claudia Wagnera...

... new drugs that approach the ideal. After reviewing Björnsson’s classification of drug action and the notion of contributory causality, this commentary defines an ideal drug from the perspectives of pharmacodynamics, pharmacokinetics, and therapeutics. Examples of new drugs for hypertension, heart...

... of chronic renal impairment on mibefradil pharmacokinetics and pharmacodynamics. Neither pharmacokinetic nor pharmacodynamic parameters varied as a function of renal status. Additionally, hemodialysis removed only a relatively small fraction of drug from the body. It was concluded that the majority of renal...