... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Clopidogrel Pharmacokinetics P-glycoprotein Polymorphism Acute myocardial infarction Dual antiplatelet therapy is the standard adhered...

...). In the present study, we investigated the effect of PMA on MDR and P-glycoprotein (P-gp) gene expression in K562/ADM cells. Methods: 3-(4,5-dimethylthiazol-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay was used to assess adriamycin (Adr)-induced cytotoxicity towards K562/ADM cells in the absence or presence...

...M. Bauer; M. Zeitlinger; D. Todorut; M. Böhmdorfer; M. Müller; O. Langer; W. Jäger We assessed the pharmacokinetics (PK), tolerability and safety of tariquidar (TQD), a P-glycoprotein (Pgp) inhibitor, after intravenous administration of single ascending doses. Employed doses were up to 4-fold...

...Chong-Ki Lee; Jun-Shik Choi Silibinin, a flavonoid, is an inhibitor of P-glycoprotein (P-gp)-mediated efflux transporters, and its oxidative metabolism is catalyzed by CYP3A4. The purpose of this study was to investigate the effect of oral silibinin on the bioavailability and pharmacokinetics...

... to systematically investigate the inhibitory and inductive effects of all glitazones on 2 of the most relevant drug transporters, P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), in vitro. Methods: The inhibition of P-gp and BCRP was assessed by fluorometric assays quantifying the increase...

... Pharmacokinetics P-glycoprotein Pharmacogenetics Abstract The aim of this work is to: (1) assess therapeutic drug monitoring of indinavir (IDV) during clinical routine practice in HIV-infected children, whose antiretroviral treatment includes IDV boosted with ritonavir (RTV), and (2) describe a possible...

... findings indicated that the MDR1 haplotype derived from C1236T, G2677T/A and C3435T is superior to predict the pharmacokinetics of digoxin. Digoxin pharmacokinetics are significantly different between individuals with the TTT-TTT haplotype and those with TGC-CGC. MDR1 haplotype P-glycoprotein Single...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. P-Glycoprotein ATP-binding cassette transporter Methadone L -α...

... of in vitro permeability, P-glycoprotein (Pgp) efflux, and plasma protein binding. Six antihistamines (acrivastine, chlorpheniramine, diphenhydramine doxylamine, fexofenadine, terfenadine) were selected based on previously reported in vitro permeability and Pgp efflux properties and dosed intravenously...

... to in the content or advertisements. ABC proteins Active transport Blood-brain barrier Membrane carrier proteins Mrp P-Glycoprotein Immunoliposomes Nanoparticles Drug targeting Oat Oatp Perspective Note Pharmacology 2004;70:169 176 DOI: 10.1159/000075545 Received: September 15, 2003 Accepted...

... was associated with cytochrome c release to the cytosol; however, at higher Taxol levels, cells became relatively resistant to the drug-induced freezing of the cell cycle and saturation thresholds for both antiproliferative and proapoptotic activity of Taxol were observed. P-Glycoprotein expression was only...

.... P-glycoprotein Multidrug resistance-associated proteins Transporters Furosemide, Vinblastine Original Paper Pharmacology 2002;64:126 134 Received: October 20, 2000 Accepted after revision: February 14, 2001 Comparison of Furosemide and Vinblastine Secretion from Cell Lines Overexpressing...

... excretion. However, erythromycin infusion did not affect biliary vinblastine excretion. These findings indicate a multiplicity of biliary excretory pathways for organic cations; at least one additonal pathway may exist for organic cations apart from P-glycoprotein. Original Paper Pharmacology 1999;59:249...

... inhibitor α,β-Unsaturated ketone CytochromeP 450 3A NADPH cytochrome P 450 reductase P-glycoprotein Original Paper Pharmacology 1999;58:147 159 Received: June 4, 1998 Accepted: August 27, 1998 In vitro Biotransformation of a Novel Antimalarial Cysteine Protease Inhibitor in Human Liver Microsomes...

...Laurent Salphati; Leslie Z. Benet Digoxin, a cardiac glycoside, is a substrate of the multidrug transporter P-glycoprotein (Pgp), and in rats has also been identified as a substrate for cytochrome P 450 3A (CYP3A). Ketoconazole, an antifungal agent, was shown to inhibit Pgp in a multidrug-resistant...