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Keywords: Oxidative stressClose
Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Amirhashem Aminizadeh, Abolfazl Yari, Fahimeh Rostamabadi, Fatemeh Bagheri, Hamid Najafipour, Mohammad Hadi Nematollahi, Arian Amirkhosravi, Mehrnaz Mehrabani, Mitra Mehrabani
Published Online: 02 November 2023
... were anesthetized, and then blood, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for subsequent serological and pathological studies. Histopathology of lung tissues was evaluated by H&E staining. The oxidative stress parameters and airway inflammation factors in BALF...
Published Online: 11 October 2023
...Wei Zhu; Lorenz S. Neuwirth; Patrick Cadet Introduction: Oxidative stress and inflammation are major factors contributing to the progressive death of dopaminergic neurons in Parkinson’s disease (PD). Recent studies have demonstrated that morphine’s biosynthetic pathway, coupled with nitric oxide...
Emine Nur Ozbek, Huseyin Istanbullu, Umran Kızrak, Elif Alan Albayrak, Gülnur Sevin, Gunay Yetik-Anacak
Published Online: 11 September 2023
... vascular relaxation and antioxidant effects by inducing H 2 S production. In the current study, we synthesized a new molecule Cpd2, as an RVT analog. We examined the effect of Cpd2 and its precursor chalcone compound (Cpd1) on H 2 S formation under both healthy and oxidative stress conditions in the lung...
Iman Saadat, Mojtaba Shakibaie, Ali Jomehzadeh, Azad Salimi, Hamid-Reza Rahimi, Seyedeh Atekeh Torabizadeh
Pharmacology (2023) 108 (1): 101–110.
Published Online: 12 January 2023
...Iman Saadat; Mojtaba Shakibaie; Ali Jomehzadeh; Azad Salimi; Hamid-Reza Rahimi; Seyedeh Atekeh Torabizadeh Introduction: Ionizing radiation (IR) causes oxidative stress in kidneys and subsequently disrupts renal function. The use of green synthesized zinc nanoparticles (Zn NPs) with antioxidant...
Rengong Zhuo, Xiaoling Cheng, Lili Luo, Luying Yang, Yun Zhao, Yu Zhou, Lu Peng, Xin Jin, Lishan Cui, Feng Liu, Lichao Yang
Pharmacology (2022) 107 (5-6): 281–289.
Published Online: 10 May 2022
...Rengong Zhuo; Xiaoling Cheng; Lili Luo; Luying Yang; Yun Zhao; Yu Zhou; Lu Peng; Xin Jin; Lishan Cui; Feng Liu; Lichao Yang Aim: Recent evidence indicates that neuroinflammation and oxidative stress play vital roles in the pathological process of major depressive disorder (MDD). Cinnamic acid (CA...
Pharmacology (2021) 106 (7-8): 369–383.
Published Online: 26 April 2021
... preconditioning also suppressed apoptosis, attenuated oxidative stress, and inhibited inflammatory responses in vivo and in vitro. Furthermore, DAP preconditioning decreased the susceptibility to ventricular arrhythmia after myocardial I/R. Finally, DAP preconditioning inhibited the expression of TLR4, MyD88...
Pharmacology (2021) 106 (5-6): 323–331.
Published Online: 29 March 2021
... with astilbin at different concentrations. Pathological changes, collagen production, inflammatory cytokine, and oxidative stress were evaluated to evaluate the effects of astilbin on CCl4-induced hepatic fibrosis. Real-time PCR and western blot were performed to detect the mRNA and protein expression...
Naseratun Nessa, Miyuki Kobara, Hiroe Toba, Tetsuya Adachi, Toshiro Yamamoto, Narisato Kanamura, Giuseppe Pezzotti, Tetsuo Nakata
Pharmacology (2021) 106 (5-6): 294–304.
Published Online: 18 March 2021
...-1β), in gingival tissue were measured using quantitative RT-PCR and immunological staining. Oxidative stress in gingival tissue was evaluated by the expression of 4-hydroxy-2-nonenal (4-HNE), and 8-hydroxy-2-deoxyguanosine (8-OHdG). To clarify the systemic effects of periodontitis, blood pressure...
Pharmacology (2020) 105 (9-10): 505–513.
Published Online: 12 August 2020
... to observe myocardial histopathology. The expression of oxidative stress-related indicators, heart tissue apoptosis-related proteins, and JNK and p-JNK proteins were measured for different groups. Results: Compared with the sham group, the T wave value of the ISO group was significantly increased ( p...
Pharmacology (2021) 106 (1-2): 37–44.
Published Online: 15 April 2020
... oxidative stress, mitochondrial dysfunction, neuro-inflammation, and even apoptosis and cell death. Principally, toll-like receptors (TLRs) could regulate the inflammatory/anti-inflammatory balance in patients with radiation-induced brain injury. Vinpocetine has an anti-inflammatory effect as shown in both...
Jian Qiu, Renjie Liu, Yaoying Ma, Yan Li, Zhuo Chen, Haiyan He, Jinliang Chen, Lijuan Tong, Chao Huang, Qingsheng You
Pharmacology (2020) 105 (9-10): 550–560.
Published Online: 23 March 2020
.... Recently, the neuroinflammatory response and oxidative stress are being attracted more and more attention due to their roles in depression pathogenesis. The inhibition of neuroinflammatory response and oxidative stress is now considered a potential strategy for depression prevention and/or therapy. Sodium...
Pharmacology (2020) 105 (9-10): 598–608.
Published Online: 31 January 2020
... the imbalance between oxidants and antioxidants, and excessive oxygen-free radicals reactive oxygen species (ROS) accelerate the development of human aging and related diseases [ 2, 3 ]. Over the past several decades, extensive investigations have indicated that linked oxidative stress to longevity using model...
Pharmacology (2020) 105 (5-6): 272–280.
Published Online: 27 November 2019
... as determined by ELISA analysis. At the tested dose, SDN causes reduction in oxidative stress via enhancing the levels of glutathione peroxidase and superoxide dismutase, while reducing the level of myeloperoxidase and malondialdehyde. Cardiac histological changes were observed via hematoxylin and eosin...
Pharmacology (2020) 105 (1-2): 109–117.
Published Online: 31 October 2019
...Jing Ma; Ranran Wang; Haijing Yan; Renjie Xu; Ajing Xu; Jian Zhang Objectives: Sepsis-induced inflammation injury and oxidative stress are well known causes of mortality. The anti-inflammatory effects of baicalin have been proposed in a mouse model of experimental sepsis. Here, we investigated its...
Zahra Lorigooini, Keyhan Sadeghi Dehsahraei, Elham Bijad, Saied Habibian Dehkordi, Hossein Amini-Khoei
Pharmacology (2020) 105 (5-6): 289–299.
Published Online: 18 October 2019
...Zahra Lorigooini; Keyhan Sadeghi Dehsahraei; Elham Bijad; Saied Habibian Dehkordi; Hossein Amini-Khoei Depression and anxiety are common psychiatric disorders accounting for social and economic burdens. Previous studies have shown that oxidative stress and oxidant/antioxidant imbalance are involved...
Pharmacology (2020) 105 (1-2): 47–53.
Published Online: 25 September 2019
... 1β and oxidative stress markers, such as malondialdehyde, superoxide dismutase, and glutathione peroxidase. Western blot analysis was used to investigate the effect of DPM on B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cleaved caspase-3. Results: Results of the study suggest...
Pharmacology (2019) 104 (3-4): 147–156.
Published Online: 30 July 2019
... for a period such as 14 or 21 days. Intracellular GSH/GSSG index in each group was detected (Fig. 3 ). The change of GSH/GSSG index is similar to that of ROS levels in each group. Fig. 2. SFN suppressed the hypoxia-mediated oxidative stress and GSH/GSSG index of osteoblasts. a The levels of ROS...
Pharmacology (2019) 104 (5-6): 258–266.
Published Online: 25 July 2019
... Oxidative stress Podocyte Diabetic nephropathy (DN) is a chronic complication of diabetes and one of the major causes of end-stage renal disorder [ 1 ]. There are several pathological changes such as thickening of tubular and glomerular basement membranes, expansion of the mesangial matrix...
Xing Li, Peigen Xie, Yu Hou, Shudong Chen, Peiheng He, Zhifeng Xiao, Jiheng Zhan, Dan Luo, Minghui Gu, Dingkun Lin
Pharmacology (2019) 104 (3-4): 187–195.
Published Online: 25 July 2019
... therapeutic effects on RA by decreasing the oxidative stress damage and regulating inflammatory cytokine expression, including suppression of the accumulation of MDA products, decreasing the IL-1β, TNF-α, IFN-γ, and PGE2 levels, enhancing the IL-10 and the activity of antioxidant enzymes, which was through...
Pharmacology (2019) 104 (3-4): 126–138.
Published Online: 18 June 2019
... (creatine kinase and lactate dehydrogenase), thiobarbituric acid reactive substance (TBARS), oxidative stress (super oxide dismutase [SOD], catalase [CAT], glutathione [GSH], and glutathione peroxidise [GPx]), histopathology, western blots analysis for B-cell lymphoma 2 (Bcl-2), Bcl-2-associated x protein...