... of atherosclerosis was evaluated by hematoxylin and eosin and Oil Red O staining in ApoE −/− mice. Molecular biomarkers of atherosclerosis progression were detected by Western blot and qPCR. Moreover, the inhibition of atherosclerosis on oxidative stress and ferroptosis was evaluated by immunofluorescence staining...

... were anesthetized, and then blood, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for subsequent serological and pathological studies. Histopathology of lung tissues was evaluated by H&E staining. The oxidative stress parameters and airway inflammation factors in BALF...

...Wei Zhu; Lorenz S. Neuwirth; Patrick Cadet Introduction: Oxidative stress and inflammation are major factors contributing to the progressive death of dopaminergic neurons in Parkinson’s disease (PD). Recent studies have demonstrated that morphine’s biosynthetic pathway, coupled with nitric oxide...

... vascular relaxation and antioxidant effects by inducing H 2 S production. In the current study, we synthesized a new molecule Cpd2, as an RVT analog. We examined the effect of Cpd2 and its precursor chalcone compound (Cpd1) on H 2 S formation under both healthy and oxidative stress conditions in the lung...

...Iman Saadat; Mojtaba Shakibaie; Ali Jomehzadeh; Azad Salimi; Hamid-Reza Rahimi; Seyedeh Atekeh Torabizadeh Introduction: Ionizing radiation (IR) causes oxidative stress in kidneys and subsequently disrupts renal function. The use of green synthesized zinc nanoparticles (Zn NPs) with antioxidant...

...Rengong Zhuo; Xiaoling Cheng; Lili Luo; Luying Yang; Yun Zhao; Yu Zhou; Lu Peng; Xin Jin; Lishan Cui; Feng Liu; Lichao Yang Aim: Recent evidence indicates that neuroinflammation and oxidative stress play vital roles in the pathological process of major depressive disorder (MDD). Cinnamic acid (CA...

... preconditioning also suppressed apoptosis, attenuated oxidative stress, and inhibited inflammatory responses in vivo and in vitro. Furthermore, DAP preconditioning decreased the susceptibility to ventricular arrhythmia after myocardial I/R. Finally, DAP preconditioning inhibited the expression of TLR4, MyD88...

... with astilbin at different concentrations. Pathological changes, collagen production, inflammatory cytokine, and oxidative stress were evaluated to evaluate the effects of astilbin on CCl4-induced hepatic fibrosis. Real-time PCR and western blot were performed to detect the mRNA and protein expression...

...-1β), in gingival tissue were measured using quantitative RT-PCR and immunological staining. Oxidative stress in gingival tissue was evaluated by the expression of 4-hydroxy-2-nonenal (4-HNE), and 8-hydroxy-2-deoxyguanosine (8-OHdG). To clarify the systemic effects of periodontitis, blood pressure...

... to observe myocardial histopathology. The expression of oxidative stress-related indicators, heart tissue apoptosis-related proteins, and JNK and p-JNK proteins were measured for different groups. Results: Compared with the sham group, the T wave value of the ISO group was significantly increased ( p...

... oxidative stress, mitochondrial dysfunction, neuro-inflammation, and even apoptosis and cell death. Principally, toll-like receptors (TLRs) could regulate the inflammatory/anti-inflammatory balance in patients with radiation-induced brain injury. Vinpocetine has an anti-inflammatory effect as shown in both...

.... Recently, the neuroinflammatory response and oxidative stress are being attracted more and more attention due to their roles in depression pathogenesis. The inhibition of neuroinflammatory response and oxidative stress is now considered a potential strategy for depression prevention and/or therapy. Sodium...

... the imbalance between oxidants and antioxidants, and excessive oxygen-free radicals reactive oxygen species (ROS) accelerate the development of human aging and related diseases [ 2, 3 ]. Over the past several decades, extensive investigations have indicated that linked oxidative stress to longevity using model...

... as determined by ELISA analysis. At the tested dose, SDN causes reduction in oxidative stress via enhancing the levels of glutathione peroxidase and superoxide dismutase, while reducing the level of myeloperoxidase and malondialdehyde. Cardiac histological changes were observed via hematoxylin and eosin...

...Jing Ma; Ranran Wang; Haijing Yan; Renjie Xu; Ajing Xu; Jian Zhang Objectives: Sepsis-induced inflammation injury and oxidative stress are well known causes of mortality. The anti-inflammatory effects of baicalin have been proposed in a mouse model of experimental sepsis. Here, we investigated its...

...Zahra Lorigooini; Keyhan Sadeghi Dehsahraei; Elham Bijad; Saied Habibian Dehkordi; Hossein Amini-Khoei Depression and anxiety are common psychiatric disorders accounting for social and economic burdens. Previous studies have shown that oxidative stress and oxidant/antioxidant imbalance are involved...

... 1β and oxidative stress markers, such as malondialdehyde, superoxide dismutase, and glutathione peroxidase. Western blot analysis was used to investigate the effect of DPM on B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cleaved caspase-3. Results: Results of the study suggest...

... group was detected (Fig.  3 ). The change of GSH/GSSG index is similar to that of ROS levels in each group. Fig. 2. SFN suppressed the hypoxia-mediated oxidative stress and GSH/GSSG index of osteoblasts. a The levels of ROS in osteoblasts were measured by DCFH-DA after treatment. b The index...

... therapeutic effects on RA by decreasing the oxidative stress damage and regulating inflammatory cytokine expression, including suppression of the accumulation of MDA products, decreasing the IL-1β, TNF-α, IFN-γ, and PGE2 levels, enhancing the IL-10 and the activity of antioxidant enzymes, which was through...

... (creatine kinase and lactate dehydrogenase), thiobarbituric acid reactive substance (TBARS), oxidative stress (super oxide dismutase [SOD], catalase [CAT], glutathione [GSH], and glutathione peroxidise [GPx]), histopathology, western blots analysis for B-cell lymphoma 2 (Bcl-2), Bcl-2-associated x protein...