...: Prescription opioids contributed to 480 of 690 prescription deaths, many co-ingestions were noted, and OR for overdose death increased with milligram of morphine equivalent (MME)/day >100. The majority who were prescribed MME >100 per day received a prescription within 90 days of overdose matching...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Adjuvant drugs Analgesia Cancer pain Morphine Opioids The European Association for Palliative Care recommends morphine along with oxycodone and hydromorphone...

... Opioids Tramadol Short Communication Pharmacology 2013;91:7 11 DOI: 10.1159/000343632 Received: July 30, 2012 Accepted after revision: September 3, 2012 Published online: October 19, 2012 Analgesic Effects of Tramadol in Combination with Adjuvant Drugs: An Experimental Study in Rats Irena Okulicz...

... of selective opioid and cannabinoid antagonists. Methods and Results: Analgesic effects of celecoxib were prevented by selective µ-(β-funaltrexamine) and δ-(naltrindole), but not ĸ-(nor-binaltorphimine) opioid antagonists, given i.c.v. 30 min before celecoxib. Similar pretreatment with AM 251, but not SR...

...Wojciech Leppert In most cancer patients, pain is successfully treated with pharmacological measures using opioid analgesics for moderate to severe pain (strong opioids) alone or in combination with adjuvant analgesics (coanalgesics). Opioids for mild to moderate pain (weak opioids) are usually...

...Megumi Shimoyama; Hazel H. Szeto; Peter W. Schiller; Yugo Tagaito; Hideyuki Tokairin; Chong moon Eun; Naohito Shimoyama Aims: H-Dmt- D -Arg-Phe-Lys-NH 2 ([Dmt 1 ]DALDA), a highly selective μ-opioid peptide, is potently analgesic after systemic and intrathecal administration but is less potent given...

...Olga Pol; Bernard Sanchez; Margarita M. Puig The study evaluates the peripheral component of the antitransit effects of opioids during acute intestinal inflammation induced by the intragastric administration of croton oil (CO) in mice. Gastrointestinal transit was measured 3 h after CO or saline...

...So C. Wong; Alphonse J. Ingenito To determine whether the peripheral opioid system participates in hypertension development we studied responses to various opioid receptor agonists in field-stimulated isolated tail artery segments taken from spontaneously hypertensive rats (SHR), normotensive...

... they were administered i.p. These data strongly support the hypothesis of a central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats. Opioids Thiorphan Gastric protection Stress 7 03 1995 10 08 1995 10 6 2008 © 1996 S. Karger AG...

.... L-364,718 Analgesia Opioids Opioid receptors Cholecystokinin C-terminal octapeptide Pharmacology 1991;42:197-201 © 1991 S. Karger AG. Basel 003 1-7012/91 /0 4 2 4 -0 197J2.75/0 Influence of the Selective Cholecystokinin Antagonist L-364,718 on Pain Threshold and Morphine Analgesia Rosanna...

...Knutn G. Helgesen; Helge Refsum Since the effects in the intact organism are complicated by central as well as peripheral effects, we compared the direct cardiac effects of three commonly used opioids on isolated heart muscle. Concentration-response curves for electrophysiological and inotropic...

...S. Ferri; E. Speroni; S. Candeletti; E. Cavicchini; P. Romualdi; P. Govoni; M. Marchini The synthetic opioid met-enkephalin analog [D-Ala 2 , MePhe 4 , Met(0) 5 ol] enkephalin (DAMME) and the opiate morphine injected intraperitoneally to rats at doses of 0.5–2 and 5–20 mg/kg, respectively, showed...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Morphine Enkephalins Opioids Mydriasis...

... by naloxone. Naloxone inhibited histamine-stimulated acid secretion even in the absence of exogenous opioids. The effect of naloxone was stereospecific, i.e. (+)-naloxone was ineffective. The DADLE effect varied between different cell preparations and changed from stimulation to inhibition as the inhibitory...

... of the vas deferens to catecholamines was observed after castration, adrenalectomy and castration with adrenalectomy. Since the responsiveness of the electrically stimulated vas deferens to β-endorphin was unchanged by this treatment (castration, adrenalectomy), it is suggested that the ‘ε-opioid’ receptor...

...J.D. Reindl; K. Rowan; A.N. Carey; X. Peng; J.L. Neumeyer; J.P. McLaughlin Previous studies have demonstrated that kappa opioid receptor (KOR) antagonists reduce stress- and depression-like behaviors. We hypothesized that administration of a novel opioid mixed agonist/antagonist capable...

... experiments are that (a) sensitization to overall reinforcement has been found more often for psychostimulants than for opioids, and that (b) tolerance to the reinforcing and other effects has been observed more often for opioids than for cocaine. These discrepancies are resolved by the finding that cocaine...

... the effect, if any, of the opioid antagonist naloxone on SSRIs-induced analgesia and tolerance employing acetic acid-induced writhing assay. Two SSRIs, fluoxetine (FLX), and citalopram (CTP) were used in the study. Acute systemic (5–40 mg kg –1 i.p.), or intrathecal (5–40 µg per mouse, i.t.) administration...

... aDepartment of Pharmacology, University of Barcelona, Odontology School, Feixa LLarga s/n, Hospitalet de LLobregat, and bDepartment of Anesthesiology, Hospital Universitario del Mar, IMIM, Barcelona, Spain Key Words Opioids W Liposomal morphine W Acute inflammation W Antinociception W Antiedema effect W Anti...