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Keywords: Onapristone
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Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1998) 56 (3): 150–157.
Published Online: 18 February 1998
... and onapristone are oxidized by cytochrome P450 (CYP) 3A4 to reactive nitroso species that complex the heme of the enzyme, thereby inactivating it. Upon preincubation with human liver microsomes in the presence (but not the absence) of NADPH, mifepristone inhibited midazolam 1′-hydroxylation, a marker of CYP3A4...
