... insight into the mechanisms through which osthole affects sciatica induced by LDH. The results indicate that our newly developed rat model maintained mechanical allodynia for 28 days without reduction. Moreover, cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) were overexpressed in the associated...

... interaction with the nitric oxide synthase (NOS) pathway. Inhibition of HO increased MAP in normotensive rats with and without hemin pretreatment but not in hypertensive rats. Pretreatment with NG-nitro- L -arginine methyl ester blocked the pressor response to ZnPP-IX, suggesting a key role of NOS...

... of nitric oxide synthase (NOS), as measured by conversion of radiolabeled L-arginine to L-citrulline, has been studied. Neither digitonin (0.01 mmol/l) nor LPC (0.01 mmol/l) influenced NOS activity in endothelial cell homogenates. Digitonin but not LPC stimulated NOS in intact endothelial cells. NOS...

... Blood-brain barrier Focal ischemia Nitric oxide synthase Original Paper Pharmacology 1994;48:367-373 Oak Za Chi Hwu Meei Wei Arabinda K. Sinha Harvey R. Weiss Departments of Anesthesia, and Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical...

...Hemendra N. Bhargava The effect of N G -monomethyl-L-arginine (NMMA), an inhibitor of nitric oxide synthase, on the development of tolerance to the analgesic and hypothermic actions of U-50,488H, a highly selective ĸ-opiate agonist, was determined in the rat. Male Sprague-Dawley rats were rendered...

...Marc J. Barjavel; Hemendra N. Bhargava Nitric oxide synthase (NOS) activity was determined by the rate of conversion of [ 3 H]arginine to [ 3 H]citrulline in brain regions (midbrain, hypothalamus, cerebellum, hippocampus, corpus striatum, cortex, pons-medulla and amygdala) and spinal cord of male...

...-arginine (5 mg/kg i.p.), an inhibitor of nitric oxide synthase. Acute administration of L-arginine (200 mg/kg i.p.) had no effect on M6G-induced antinociception, but higher doses (400 and 800 mg/kg i.p.) decreased it. Since the antinociceptive response to centrally administered M6G was unaffected...

...Shou Zhen Wang; Seok Yong Lee; Sheng Zu Zhu; Esam E. El-Fakahany The selectivity of coupling of m1, m3, and m5 muscarinic receptors to activation of the neuronal type of nitric oxide synthase was investigated. Stimulation with the agonist carbachol of all three receptor subtypes expressed...

.... Endothelin-1 Guanosine triphosphate cyclohydrolase I Mesangial cells Nitric oxide synthase 9 05 1996 16 07 1996 10 6 2008 Pharmacology Original Paper Pharmacology 1996;53:241-249 Junichi Himhashia Toshio Nakakib Keiichi Hishikawaa Takeshi Marumoa Toshio Yasumorih Matsuhiko Hayashia...

...Maria del Pilar Fernandez-Rodriguez; Angel Belmonte; Maria Jose Meizoso; Manuel Garcia-Novio; Elisardo Garcia-Iglesias The effect of the 21-aminosteroid tirilazad mesylate (10 mg/ kg, i.p.) on nitric oxide synthase (NOS) activity in the brain cortex was studied in male Wistar rats subjected...

... oxide. On the basis of reports that bradykinin translocates nitric oxide synthase (NOS) from the membrane to the cytosol, we investigated whether a similar translocation occurs with LPC. It was found that LPC translocated NOS from the membrane to the cytosolic fraction. Total NOS activity remained...

...Hemendra N. Bhargava; Shailendra Kumar Effects of multiple administrations of cocaine and subsequent cocaine withdrawal on the activity of nitric oxide synthase (NOS) in brain regions and spinal cord of male Swiss-Webster mice were determined. Chronic administration of cocaine resulted...

...-nitric-oxide-synthase (iNOS)-selective inhibitor 1400W or the endothelial nitric oxide synthase (eNOS)/iNOS nonselective blocker L -NAME. The presence of endothelium did not alter these findings. Administering LPS to SV-treated rats also decreased the SBP and increased the NO x concentration...

.... Grönig A. Atalla K. Kuschinsky Institute of Pharmacology and Toxicology, Faculty of Pharmacy, University of Marburg, Marburg, Germany Key Words Cocaine sensitization Conditioning stimulus Dopamine NMDA receptors Nitric oxide synthase Abstract After repeated administration of psychostimulant drugs...

...Sarit Offer; Abraham Eliraz; Gershon Fink; Aliza H. Stark; Zecharia Madar This study investigated interactions between nitric oxide synthesis and phospholipase A 2 (PLA 2 ) activation in lung epithelial cells. Nitrite formation, inducible nitric oxide synthase expression, and [ 3 H]arachidonic acid...

...Zecharia Madar; Shiri Kalet-Litman; Aliza H. Stark Inducible nitric oxide synthase (iNOS) is expressed by the liver in a number of physiological and pathophysiological conditions. The aim of this study was to investigate the relationship between the diabetic state, iNOS and oxidative stress...

... the hearts of 9 rabbits. Myocyte function was studied using a video-edge detector and cyclic GMP levels were measured by radioimmunoassay. Cells were administered 5 and 10 mmol/l ethanol alone or after 10 –6 mol/l N G -nitro- L -arginine methyl ester ( L -NAME, nitric oxide synthase inhibitor), 10 –6 mol/l...

...Hou-Bo Jiang; Hirohito Yoneyama; Aizo Furukawa; Tatsuhichiro Hamamoto; Jirou Takahara; Yoshiyuki Ichikawa Nitric oxide synthase (NOS) catalyzes nitric oxide (NO) formation from L -arginine in the presence of molecular oxygen and NADPH. NO is involved in the regulation of microvasculature...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nitric oxide synthase 7-Nitroindazole 1-(2-Trifluoromethylphenyl...

... (calcium channel antagonist) on constitutive nitric oxide synthase (cNOS) activity and cyclic guanosine monophosphate (cGMP) levels in brain homogenates of rats subjected to global cerebral transient ischemia induced by bilateral clamping of the carotids for 30 min and reduction of arterial pressure (to 50...