...-deficient ( Gper -/- ) mice (4 and 24 months old). In wild-type mice, aging markedly impaired endothelium-dependent, nitric oxide (NO)-mediated relaxations to acetylcholine, which were largely preserved in renal arteries of aged Gper -/- mice. The Nox inhibitor gp91ds-tat abolished this difference...

... atypical agents. In this study, we investigated the effect of aripiprazole on seizure of mice in sub-chronic treatments. We also examined the interaction of nitric oxide (NO) with aripiprazole in seizure experiments. Mice received aripiprazole for 6 days and then on the 7th day aripiprazole was injected 60...

...-dependent nitric oxide/soluble guanylyl cyclase/cyclic guanosine monophosphate signalling pathway. In order to investigate the calcium entry blocking properties of the studied compounds, they were tested on isolated rat aorta precontracted with KCl, as we described before [ 12 ]. Briefly, the aorta...

... + /Ca 2+ exchanger 1 Smooth muscle Nitric oxide Relaxation Gastrointestinal motility Moving the contents of the gastrointestinal tract relies on the coordinated contractions and relaxations of the smooth muscles that surround each specialized region. Ca 2+ entry signals are crucial...

... the role of the endothelium-derived relaxing factors on the vascular effects of organophosphates. This study was carried out to evaluate the vascular effects of malathion and the role of nitric oxide (NO) and prostacyclin (PGI 2 ). Methods: Vascular reactivity measuring isometric forces in vitro (‘organ...

...Kazuhiro Nishiyama; Yasu-Taka Azuma; Kazuma Shintaku; Natsuho Yoshida; Hidemitsu Nakajima; Tadayoshi Takeuchi The gastrointestinal tract is composed of outer longitudinal muscle layers and inner circular muscle layers. Nitric oxide (NO), carbon monoxide (CO), and ATP play major roles as non...

...SeongHun Yoon; Mario Zuccarello; Robert M. Rapoport This study investigated whether cocaine constriction of rat basilar artery in situ is mediated by nitric oxide (NO) inhibition and/or endothelin (ET)-1 release. Cocaine (3-100 µmol/l) concentration-dependently constricted the basilar artery...

... sensory nerves and nitric oxide (NO). The aim of the present study is to examine which isoform of nitric oxide synthase (NOS)/NO is involved in the hyperemic response to capsaicin in the rat stomach. Methods: Gastric mucosal blood flow (GMBF) was measured by laser Doppler flowmetry in rats...

... to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice. Male Swiss mice (26–32 g) were used as the in vivo model. The following pharmacological tools were utilized: the non-selective NO synthase (NOS) inhibitor L -NAME (10 mg/kg, i.p...

... concentration in diabetic rats. rHuEPO also decreased the level of the receptor for advanced glycation end products in the aorta. We also found an increased expression of phospho-Akt and endothelial nitric oxide synthase and plasma NOx level in the rHuEPO-treated group. On the other hand, rHuEPO did not affect...

... pathways in long-term-diabetic rats. 19 04 2012 16 07 2012 29 8 2012 Original Paper Pharmacology 2012;90:169 176 DOI: 10.1159/000341911 Received: April 19, 2012 Accepted after revision: July 16, 2012 Published online: August 29, 2012 The Cyclooxygenase and Nitric Oxide Synthesis...

...-HD. The cardioprotective effects were blocked by a nonselective nitric oxide synthase (NOS) inhibitor ( L -NAME) following acute administration and by a selective iNOS inhibitor (1400W) following chronic administration. Conclusion: These results suggest that EP 94 may have potential for the treatment...

... and diabetic rats. The response to des-Arg 9 -BK or enalaprilat was blocked by Lys-(des-Arg 9 , Leu 8 )-BK (a B 1 receptor antagonist) and N-nitro- L -arginine methyl ester (an inhibitor of nitric oxide synthase). These results suggest that enalaprilat activates B 1 receptors and stimulates the production...

...Jer-Young Liou; Hong-Jye Hong; Li-Chin Sung; Hung-Hsing Chao; Po-Yuan Chen; Tzu-Hurng Cheng; Paul Chan; Ju-Chi Liu Background/Aims: Nicorandil, an ATP-sensitive potassium (K ATP ) channel opener, nitric oxide (NO) donor and antioxidant, was shown to exert a variety of pharmacological effects...

...Jie Li; Zhi-Zhong Xie; Yong-Bo Tang Genistein has been shown to increase nitric oxide (NO) production derived from endothelial nitric oxide synthase (eNOS). This study was to investigate whether genistein could prevent myocardial hypertrophy in the 2-kidney 1-clip (2K1C) renohypertensive rat...

.... In the isolated carotid artery, treatment with HET0016 corrected the L -NAME-induced increase in norepinephrine-induced vasoconstriction, whereas only CDU treatment could improve impaired carbachol-induced vasodilation. Results of this study indicate that vascular function in a state of compromised nitric oxide...

... using an isometric force transducer. Low-frequency EFS induced only off-contraction, but induced on-contraction in the presence of N G -nitro- L -arginine methyl ester, suggesting that nitric oxide acts as an inhibitory mediator in smooth muscle. The excitatory composition of both contractions...

...-panel runway task. The negative effects of 7-NI on reference memory was counteracted by L -arginine, a substrate for nitric oxide synthase. While having no effect on the number of working memory errors in working memory trials, 7-NI prolonged the latency from the 2nd to the 6th trial at the 5- and 10-mg...

... pressure (PAP) and subsequent administration of an equimolar dose of l -arginine did not affect PAP. l -Glutamine at a dose of 0.5 m M transiently increased PAP, which then decreased to baseline (pre-glutamine) values. When endogenous nitric oxide (NO) synthesis was inhibited with N G -nitro- l -arginine...

... Jefferson University Hospital, Philadelphia, and b SmithKlinc Beecham Laboratories, King o f Prussia, Pa., USA Key Words Nitric oxide Carvedilol Endothelial function Free radicals Carvedilol, a New Beta-Adrenoreceptor Blocker Antihypertensive Drug, Protects against Free-Radical-Induced Endothelial...