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Keywords: Nitric oxide
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (3-4): 188–193.
Published Online: 14 July 2017
...-deficient ( Gper -/- ) mice (4 and 24 months old). In wild-type mice, aging markedly impaired endothelium-dependent, nitric oxide (NO)-mediated relaxations to acetylcholine, which were largely preserved in renal arteries of aged Gper -/- mice. The Nox inhibitor gp91ds-tat abolished this difference...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2015) 94 (5-6): 230–238.
Published Online: 26 November 2014
... + /Ca 2+ exchanger 1 Smooth muscle Nitric oxide Relaxation Gastrointestinal motility Moving the contents of the gastrointestinal tract relies on the coordinated contractions and relaxations of the smooth muscles that surround each specialized region. Ca 2+ entry signals are crucial...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 94 (3-4): 157–162.
Published Online: 03 October 2014
... the role of the endothelium-derived relaxing factors on the vascular effects of organophosphates. This study was carried out to evaluate the vascular effects of malathion and the role of nitric oxide (NO) and prostacyclin (PGI 2 ). Methods: Vascular reactivity measuring isometric forces in vitro (‘organ...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 94 (3-4): 99–108.
Published Online: 13 September 2014
...Kazuhiro Nishiyama; Yasu-Taka Azuma; Kazuma Shintaku; Natsuho Yoshida; Hidemitsu Nakajima; Tadayoshi Takeuchi The gastrointestinal tract is composed of outer longitudinal muscle layers and inner circular muscle layers. Nitric oxide (NO), carbon monoxide (CO), and ATP play major roles as non...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 93 (3-4): 151–154.
Published Online: 25 April 2014
...SeongHun Yoon; Mario Zuccarello; Robert M. Rapoport This study investigated whether cocaine constriction of rat basilar artery in situ is mediated by nitric oxide (NO) inhibition and/or endothelin (ET)-1 release. Cocaine (3-100 µmol/l) concentration-dependently constricted the basilar artery...
Journal Articles
Journal Articles
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Journal Articles
Journal Articles
Pharmacology (2011) 87 (3-4): 195–203.
Published Online: 25 March 2011
... and diabetic rats. The response to des-Arg 9 -BK or enalaprilat was blocked by Lys-(des-Arg 9 , Leu 8 )-BK (a B 1 receptor antagonist) and N-nitro- L -arginine methyl ester (an inhibitor of nitric oxide synthase). These results suggest that enalaprilat activates B 1 receptors and stimulates the production...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2011) 87 (3-4): 144–151.
Published Online: 22 February 2011
...Jer-Young Liou; Hong-Jye Hong; Li-Chin Sung; Hung-Hsing Chao; Po-Yuan Chen; Tzu-Hurng Cheng; Paul Chan; Ju-Chi Liu Background/Aims: Nicorandil, an ATP-sensitive potassium (K ATP ) channel opener, nitric oxide (NO) donor and antioxidant, was shown to exert a variety of pharmacological effects...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2010) 86 (4): 240–248.
Published Online: 13 October 2010
...Jie Li; Zhi-Zhong Xie; Yong-Bo Tang Genistein has been shown to increase nitric oxide (NO) production derived from endothelial nitric oxide synthase (eNOS). This study was to investigate whether genistein could prevent myocardial hypertrophy in the 2-kidney 1-clip (2K1C) renohypertensive rat...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (6): 346–355.
Published Online: 03 November 2009
... using an isometric force transducer. Low-frequency EFS induced only off-contraction, but induced on-contraction in the presence of N G -nitro- L -arginine methyl ester, suggesting that nitric oxide acts as an inhibitory mediator in smooth muscle. The excitatory composition of both contractions...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (4): 211–218.
Published Online: 05 September 2009
...-panel runway task. The negative effects of 7-NI on reference memory was counteracted by L -arginine, a substrate for nitric oxide synthase. While having no effect on the number of working memory errors in working memory trials, 7-NI prolonged the latency from the 2nd to the 6th trial at the 5- and 10-mg...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1996) 53 (3): 151–159.
Published Online: 10 June 2008
... response in normal rings while significantly attenuating those responses in diabetic rings. N G -nitro-L-arginine methyl ester (100 nmol/l), an inhibitor of nitric oxide synthase, significantly potentiated the contractile response of 5-HT in normal as well as diabetic pulmonary arterial rings. The results...