...Jun Sun; Wei Dou; Hong Shen; Jinhong Hu Background: Proteinase-activated receptor 2 (PAR2) may be implicated in skin disorders. Intracellular calcium mobilization is a key step in PAR2-induced signaling. Aims: In this study, we investigated the effects of nifedipine, verapamil, and low-molecular...

... of indometacin and nifedipine completely blocked the diarrhoea induced by rhein anthrone and also inhibited its effects on colonic fluid and electrolyte transport, and large intestinal motility. Calmodulin antagonists were less active regarding suppression of the effects of rhein anthrone. We concluded...

...Giora Z. Feuerstein; Marc Fisher; J. Nunnari; Robert R. Ruffolo, Jr. The effects of carvedilol, a vasodilating β-blocker with antioxidant activity, and nifedipine, a calcium channel blocker, were investigated on aortic lipid deposition and the accumulation of monocytes and foam cells at the sites...

...M.A. Noguera; S. Chulia; M. Elorriaga; M.D. Ivorra; P. D’Ocon The influence of the divalent cations, Ca 2+ , Mg 2+ and Ba 2+ , on the contractile response of the rat aorta to KCl and on the recovery of this response after nifedipine treatment was analyzed. KCl (80 mmol/l) promoted a two-phase...

... decreased: 8.2 ± 3.7, 2.9 ± 1.4, 1.2 ± 0.7, 0.6 ± 0.2 µg/min (mean ± SD), respectively. Nifedipine and diltiazem were also studied in hearts perfused with 3 and 9 mmol/l [K] + . Infusion of nifedipine 0.003-1 µg/min (approximately 10 –9 to 3 × 10 –7 mol/l) produced concentration-dependent reduction of left...

... Signal Transduction Processes in Vascular Smooth Muscle Keywords a i-Adrenoceptors Phenoxybenzam ine Signal transduction Aorta, rat Nifedipine Norepinephrine Dobutamine Abstract Full ai-adrenoceptor agonists, such as norepinephrine, produce va­ soconstriction in the rat aorta pri­ marily through...

... affect contractile responses to Bay K 8644 in either strain of rats. There were no differences in contractile responses to the calcium ionophore A23187 or in nifedipine-induced relaxation of potassium-activated vessels between carotid arteries from SHRSP and WKY rats. In summary, these results suggest...

...) and nifedipine. Pr-MDI exhibits intracellular calcium antagonistic and calcium channel blocking properties in this tissue, while nifedipine acts principally as a calcium channel blocker. Thoracic strips from young (4–6 months old) and senescent (22–23 months old) Fischer F344 rats were contracted with KCl (10–60...

...P. Koch; D. Wilhelm; B. Wilffert; T. Peters The interaction of the benzothiazolamine R 56865 with the nifedipine-sensitive component of the serotonin (5-HT)-, angiotensin II (AII)- and arginine-vasopressin (AVP)-induced contractions was studied in the isolated rat aorta. Nifedipine caused...

...P.K. Janicki; D. Siembab; E.A. Paulo; P. Krzaścik Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 mg/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light...

...T.H. Dickinson; J.M. Egan; D.R. Abernethy To determine whether inhibition of drug oxidation is a general property of all calcium antagonist drugs or just of a few, we measured effects of therapeutic doses of nifedipine on antipyrine biotransformation. Antipyrine was administered in random order...

... or chemical sympathectomy or treatment with captopril did not prevent the development of CdCl 2 -induced hypertension. Treatment with verapamil (15 mg/kg/day, p.o.) or nifedipine (10 mg/kg/day, p.o.) for 2 weeks prevented the development of hypertension with chronic CdCl 2 treatment. It is suggested...

...Elisardo C. Vasquez; Antonio M. Cabral; José G. Mill; Margareth R. Moyses The effects of nifedipine (15 μg/kg, i.v.) on mean blood pressure (MBP) and heart rate were studied in neurogenic hypertensive rats (NHR), compared with renovascular hypertensive (RHR), and control (CR) rats. The maximal MBP...

...Shoji Shibata; Nobuhiro Satake In the renal and femoral artery, nicorandil (10 –6 –10 –4 mol/l) had a much greater inhibitory effect on the responses to clonidine (CL) and BHT-920 than on the response to methoxamine (MO) but the inhibitory action of nifedipine on the responses was not different...

... and exposed to 5HT (4 × 10 –7 M ) and anoxia (95% N 2 and 5% CO 2 ). Developed tension was increased by 250 ± 40 mg by 5HT alone and 2,000 ± 90 mg by 5HT and anoxia. Calcium (5 m M ) potentiated, while inorganic (lanthanum, 10 –2 M ) and organic calcium antagonists (nifedipine, verapamil and diltiazem; IC 50...

...Y. Nakagawa; M. Gudenzi; Jamal Mustafa Calcium entry blocking activities of adenosine and its potentiating compounds (dipyridamole, lidoflazine and dilazep) were studied in potassium (100 mmol/l) depolarized, dog, large coronary artery strips, in comparison to nifedipine, verapamil and diltiazem...

...S.R. Hamann; T.G. Tan; K.E. Kaltenborn; K.L.R. Brouwer; R.A. Blouin; S.L. Chang; M. Vore; R.G. McAllister, Jr. Both verapamil and nifedipine are first-generation calcium-entry antagonist drugs which are eliminated by hepatic metabolism. To evaluate the effects of enzyme induction and suppression...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Bepridil hydrochloride Diltiazem hydrochloride Verapamil hydrochloride Nifedipine Propranolol Lidocaine Cardiac...

...Tae-Seong Lee; Toshihiko Kaku; Satoshi Takebayashi; Tomoko Uchino; Shinji Miyamoto; Tetsuo Hadama; Edward Perez-Reyes; Katsushige Ono We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L-type Ca 2+ channels expressed...

...Takahiro Kato; Atsuo Amano; Yoshinori Kamisaki; Ichijiro Morisaki Nifedipine (NIF), a calcium channel blocker, is well known to induce gingival overgrowth (GO) as an adverse effect, and ketoconazole (KTZ), an azole antifungal agent, has been implicated in various drug interactions. We here examined...