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Keywords: Muscarinic receptors
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 92 (5-6): 286–302.
Published Online: 29 November 2013
... glands. Thus, it can hardly be discriminated between effects caused by the neuronal or the non-neuronal cholinergic system. However, it is well known that neuronally released ACh triggers mucus secretion and bronchoconstriction via muscarinic receptors that limit airflow [ 40 ]. nAChR were also...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 83 (5): 301–317.
Published Online: 28 April 2009
...Meredith J. Noetzel; Marianne K.O. Grant; Esam E. El-Fakahany Background/Aims: Xanomeline has been shown to bind in a unique manner at M1 and M3 muscarinic receptors, with interactions at both the orthosteric site and an allosteric site. We have previously shown that brief exposure of Chinese...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1992) 44 (6): 324–333.
Published Online: 06 June 2008
... postconfluence and between 10 and 25 passage numbers. Utilizing radioligand binding techniques with the muscarinic receptor antagonists [ 3 H]3-quinuclidinyl benzilate ([ 3 H]QNB) and [ 3 H]N-methylscopolamine ([ 3 H]MS) as probes, we identified a small population of atropine-sensitive muscarinic sites (1,800...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1990) 40 (5): 241–249.
Published Online: 05 June 2008
...Mario Del Tacca; Romano Danesi; Corrado Blandizzi; Maria C. Bernardini The pA 2 values and the Schild plots of the antimuscarinic drugs AF-DX 116, atropine and pirenzepine for muscarinic receptors of isolated guinea pig gastric fundus (acid secretion) and atrial and urinary bladder preparations...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 38 (6): 374–380.
Published Online: 05 June 2008
.... Antispasmodic agents Intestinal motility Muscarinic receptors Migrating myoelectrical complex Abstract. DF 594, 1l-(N-methylnipecotyl)-6,l l-dihydro-5H-pyrido[2,3-b]-l,5-benzodiazepin-5-one hydrochloride, is a new antimuscarinic compound endowed with high affinity for intestinal muscarinic receptors...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 37 (4): 225–231.
Published Online: 05 June 2008
.... Antidepressants Muscarinic receptors Histamine H 1 , H 2 receptors Competitive antagonists Side effects Pharmacology 37: 225-231 (1988) © 1988 S. Karger AG. Basel 0031 -7012/88/0374-022552.75/0 Blockade of Muscarinic, Histamine H, and Histamine H 2 Receptors by Antidepressants F J. Alvarez, A. Velasco...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 37 (Suppl. 1): 17–21.
Published Online: 05 June 2008
... regulating acid secretion remains unclear. Studies with parietal cells isolated from several species indicate that parietal cells have a muscarinic receptor with low affinity for the M1-antagonists. Our studies with somatostatin cells isolated from canine fundic mucosa indicates that the muscarinic receptor...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 37 (Suppl. 1): 22–31.
Published Online: 05 June 2008
...N.J.M. Birdsall; C.A.M. Curtis; P. Eveleigh; E.C. Hulme; E.K. Pedder; D. Poyner; M. Wheatley Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1981) 22 (3): 189–195.
Published Online: 30 May 2008
...J. Morisset; L. Geoffrion; L. Larose; J. Lanöe; G.G. Poirier We have studied the binding of the potent muscarinic antagonist, ( 3 H)-quinuclidinyl benzilate [( 3 H)-QNB], in order to characterize muscarinic receptors of the digestive tract organs and evaluate their population. In each tissue...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2005) 74 (2): 100–105.
Published Online: 26 May 2005
..., instructions or products referred to in the content or advertisements. Muscarinic receptors Cevimeline Sicca syndrome Salivary amylase Original Paper Pharmacology 2005;74:100 105 DOI: 10.1159/000084031 Received: July 1, 2004 Accepted after revision: December 28, 2004 Published online: February 18...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2002) 65 (4): 215–221.
Published Online: 12 July 2002
... of deoxycholic acid (DC) act as cholinergic muscarinic receptor antagonists. Chinese hamster ovary (CHO) cells expressing rat M3-muscarinic receptors were used to test bile acids for inhibition of radioligand [N- 3 H-methylscopolamine ( 3 H-NMS)] binding; alteration of inositol phosphate (IP) formation; mitogen...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2002) 64 (4): 182–188.
Published Online: 06 March 2002
... induced contractions in the presence of L -NMMA (E max = 34%). The muscarinic receptor antagonists atropine (no selectivity), pirenzepine (M 1 ), methoctramine (M 2 ), and p -fluoro-hexahydro-sila-difenidol (M 1 /M 3 ) competitively antagonized the response to ACh. The pA 2 values were 9.60 ± 0.10, 6.99...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2002) 64 (3): 148–151.
Published Online: 07 February 2002
.... For determination of M 3 muscarinic receptor mRNA in the bladder tissue, the method of Northern blotting was employed. The results of the Western immunoblotting showed that the amount of M 3 -mAChR protein in the diabetic bladder was significantly increased by about 70.2 ± 8.5% when compared to the control bladder...