...Claire R. Galloway; Evan P. Lebois; Shezza L. Shagarabi; Norma A. Hernandez; Joseph R. Manns Acetylcholine signaling through muscarinic receptors has been shown to benefit memory performance in some conditions, but pan-muscarinic activation also frequently leads to peripheral side effects. Drug...

...Shíno Adachi; Katsuo Koike; Issei Takayanagi The present study was designed to investigate which muscarinic receptors the indoline derivatives interact with and also their pharmacological properties. Compounds I and II contracted guinea-pig ileum in a concentration-dependent manner, whereas...

...Jingru Hu; Shou Zhen Wang; Serena Scapecchi; Fulvio Gualtieri; Esam E. El-Fakahany Characteristics of interaction of two derivatives of 2,2-diphenyl-2-ethylthioacetate with muscarinic receptors were studied in Chinese hamster ovary (CHO) cells stably transfected with the genes of human m2 and m3...

...Jennifer S. Kiefer-Day; El-Sayed A.M. Abdallah; Carlos Forray; Norman H. Lee; Ok Nyu Kim; Esam E. El-Fakahany The purpose of this study was to investigate the effects of 9-amino-1,2,3,4-tetrahydroacridine (THA; Tacrine®) on muscarinic-receptor-linked second-messenger systems in rat brain...

...Jingru Hu; Esam E. El-Fakahany Interaction of the basic peptides dynorphin A and myelin basic protein with muscarinic receptors was investigated in rat heart and cerebral cortex using radioligand receptor binding assays. Results showed that these peptides inhibit the binding of the muscarinic...

.... Following 3 mg/kg THA, drug levels in brain were sufficient to inhibit 78-80% of brain acetylcholinesterase activity, regardless of treatment duration. However, repeated administration of THA did not alter the number of muscarinic receptors or the phosphoinositide response to muscarinic receptor agonists...

...B.S. Qiu; C.H. Cho; S.C.G. Hui; C.W. Ogle Chronic nicotine administration depresses the autonomic ganglia, but its effects on the muscarinic receptors at the neuroeffector sites remain unclear. The present study, using rats, examines the influence of chronic treatment with nicotine (25 µg/ml...

... of these findings, the antiulcer activity of esaprazole might be in part ascribed to its inhibitory effects on gastric secretion. Gastric ñstula Heidenhain pouch Dogs Acid secretion Gastrin plasma levels Muscarinic receptor antagonists Esaprazole 8 11 1991 1 05 1992 6 6 2008 © 1993...

... rat. Cholinergic (muscarinic) receptors as well as the benzodiazepine receptors were in significantly higher density in the desert rat. The affinity was low for muscarinic receptors in the desert rat but equal for benzodiazepine receptors in both species. Since there are more alpha-adrenergic...

...) but not by AF-DX 116 (3 μmol/l). It is concluded that Ml receptors mediate the excitatory actions of muscarinic agonists in these sympathetic ganglia. Autonomic ganglion Muscarinic receptor Slow EPSP M-current Pirenzepine Telenzepine AF-DX 116 © 1988 S. Karger AG, Basel 1988 Copyright / Drug...

... receptors to modulate acetylcholine releases in cholinergic nerve endings in human detrusor smooth muscles. The findings support that muscarinic-receptor-inhibitory actions in human bladder mainly contribute to the usefulness of solifenacin as a therapeutic drug for overactive bladder. Original Paper...

... to muscarinic receptors but the true meaning of this feature needs to be clarified. In conclusion, these data suggest that procaine exerts neuroprotective properties and may serve either as a treatment for AD or as a starting point for the development of novel therapies for AD. Alzheimer’s disease...