...Luisa Vargas; Luisa Gonzalvez; Antonio Martinez; Lourdes Arias; Arturo J. Bruger; Victoria Milanés The effects of systemically administered clonidine on pituitary-adrenocortical axis in morphine-tolerant rats and after naloxone-induced withdrawal were examined. In naive animals, clonidine (0.5...

...M.M. Ho; S. Dai; C.W. Ogle The gastric mucosa and basal gastric secretion of morphine-dependent rats with pyloric occlusion were examined. Morphine tolerance and dependence were induced by administering increasing concentrations of morphine sulphate in the drinking water for 3 weeks, and were...

...L. Tamayo; E. Contreras Effects of valproic acid administration on morphine analgesia and on morphine tolerance and dependence were investigated in mice. Valproate increased the reaction time to thermal stimulation in naive animals. This effect was additive with morphine when valproate...

...Li He; Jennifer L. Whistler We have recently demonstrated that the combination of methadone and morphine enhances the ability of morphine to induce µ-opioid peptide (MOP) receptor endocytosis. As a result, rats receiving both drugs show reduced morphine tolerance and dependence. In the present...

... transmission postsynaptically by enhancing NMDA receptor responsiveness. So we used the clinically available NMDA receptor antagonist, dextromethorphan, and the neurotrophin 4 antibody, anti-NT4, concomitantly and alone to investigate their effects on morphine tolerance. Tolerance was induced by injecting...

.... Morphine tolerance Neonatal rats Antinociception Receptor binding Original Paper Pharmacology 2002;66:11 18 Received: October 5, 2001 Accepted after revision: December 14, 2001 Loss of Antinociceptive Efficacy in Rat Pups Infused with Morphine from Osmotic Minipumps Dawn C. Stoller Suzanne R...