...L. Tamayo; E. Contreras Effects of valproic acid administration on morphine analgesia and on morphine tolerance and dependence were investigated in mice. Valproate increased the reaction time to thermal stimulation in naive animals. This effect was additive with morphine when valproate...

...J. Fishman; E.F. Hahn; B.I. Norton; A. Rona; F.F. Foldes The use of a non-biodegradable polymer system to provide a sustained release of the narcotic antagonist naloxone in rats is described. The kinetics of morphine analgesia (measured by the hot-plate test) in the presence of the naloxone implant...

... but it increased morphine analgesia with both methods studied and decreased the antinociceptive effect of tricyclic antidepressants, especially that of protriptyÜne, in the hot plate method. This result supports the view that the mechanism of analgesic action of morphine may be different from that of tricyclic...

...Shaifali Bhalla; George Matwyshyn; Anil Gulati Several neurotransmitter mechanisms have been proposed to play a role in the actions of morphine. We reported that centrally administered endothelin A (ET A ) receptor antagonists potentiate morphine analgesia in rats. It has also been reported that ET...