... groups ( n = 10). They were treated with (i) normal saline (10 mL/kg), (ii) morphine (10 mg/kg), (iii) morphine plus naloxone (10 + 4 mg/kg), and (iv) naloxone (4 mg/kg) for 2 weeks. Four groups of MDA-MB-231 cells were administered (i) Dulbecco’s Modified Eagle’s Medium, (ii) morphine (10 μmol/mL), (iii...

...Wojciech Leppert; Irena Okulicz-Kozaryn; Ewa Kaminska; Michal Szulc; Przemyslaw Mikolajczak Background: Morphine is co-administered with adjuvant drugs to treat pain, nausea, vomiting, dyspnoea and delirium in cancer patients. Aim of the Study: To investigate analgesic effects of morphine when co...

...-ARs) may play a critical role in the consolidation of long-term memory. The present study examines the possible role of β 1 -ARs located in the mPFC on morphine-induced amnesia in rats. The animals were bilaterally implanted with chronic cannulas in the mPFC, trained in a step-through-type passive...

... receptor antagonist, the effect of this ion on the analgesic action of morphine was compared with that of MK-801. Acute pain was evoked by mechanical or thermal stimuli, whereas neuropathic hyperalgesia was induced by streptozotocin (STZ) administration. Magnesium sulphate (40 mg/kg i.p.) or MK-801 (0.05...

...Shaifali Bhalla; Shridhar V. Andurkar; Anil Gulati Objectives: The potentiation of morphine or oxycodone analgesia by endothelin-A (ET A ) receptor antagonists and imidazoline/α 2 -adrenergic agonists is well documented. However, the effect of morphine or oxycodone in combination with an ET...

...Rita Benko; Zsuzsanna Molnár; Dániel Nemes; András Dékány; Dezsö Kelemen; Lászlo Illényi; Lászlo Cseke; András Papp; Gábor Varga; Loránd Bartho Background/Aims: Morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small...

...Anil Gulati; Shaifali Bhalla; George Matwyshyn; Zhong Zhang; Shridhar V. Andurkar Background: Numerous agents have been demonstrated to potentiate morphine analgesia, including clonidine (α 2 -adrenergic and I 1 -imidazoline receptor agonist) and BMS182874 (endothelin-A, ET A, receptor antagonist...

... intracerebroventricularly. This study was performed to further characterize the analgesic effects of [Dmt 1 ]DALDA. Methods: We compared the effects of [Dmt 1 ]DALDA and morphine after systemic administration in two different acute pain tests, the tail flick test and the paw withdrawal test, and examined how antagonizing...

... agonists and (2) the effect of the magnesium ions (Mg 2+ ) on the antinociceptive action of opioid agonists in a diabetic neuropathic pain model. When administered alone, opioid agonists like morphine (5 mg/kg i.p.) and fentanyl (0.0625 mg/kg i.p.), as well as the partial agonist buprenorphine (0.075 mg/kg...

... as saline control, group 2 was treated with morphine (1 mg/kg/day for 7 days) and group 3 was treated with naloxone (2 mg/kg/day for 7 days). Following the third day of morphine injection, rats showed restlessness, hyperactivity, increased urination, diarrhea, lacrimation, irritability and squealing...

...Hemendra N. Bhargava; George A. Matwyshyn The effect of dizocilpine (MK-801), an N-methyl- D -aspartate receptor antagonist, on the development of tolerance to the analgesic and hyperthermic effects of morphine was determined in the rat. Tolerance to morphine in male Sprague-Dawley rats was induced...

...Hemendra N. Bhargava; Vincent M. Villar; Nafasat H. Rahmani; Karl Larsen Previously it was demonstrated that intravenously administered morphine produced greater analgesic but lower hyperthermic responses to morphine in 24-week-old rats in comparison to 8-week-old rats. The differential...

...Alexander Mosner; Gabriele Kuhlman; Cordula Roehm; Wolfgang H. Vogel Effects of fluvoxamine, a relatively selective 5-HT uptake inhibitor, and ipsapirone, a relatively selective 5-HT1A agonist, were studied on the initiation and/or maintenance of the voluntary intake of alcohol, morphine, cocaine...

...M. Bianchi; R. Maggi; A.E. Panerai; L. Martini The effects of subcutaneous pretreatment with the glucocorticoid/progesterone receptor antagonist RU 486 on the antinociceptive action of peripherally administered morphine were evaluated by the hot-plate test in mice. The steroid significantly reduced...

.... However, little information exists on whether opioid administration affects concentrations of brain GSH. Recently, clinical observations have indicated acute declines of GSH concentrations in the cerebrospinal fluid of cancer patients after acute intracerebroventricular (ICV) morphine which may contribute...

... and least effective on TF hyperalgesia, while indometacin and morphine produced their main effect on TF hyperalgesia. The four drugs were about equally effective in reversing HP hyperalgesia. We conclude that ET hyperalgesia is mediated by both prostaglandin-sensitive and prostaglandin-independent...

...Peter T. Thomas; Hemendra N. Bhargava; Robert V. House Both in vivo and in vitro exposure to morphine have been reported to produce a number of immunomodulatory effects in both laboratory animals and humans. The current study was performed to assess the direct in vitro effect of exposure...

...Vincent M. Villar; Hemendra N. Bhargava The decay characteristics of tolerance and physical dependence on morphine induced by a pellet implantation procedure were determined in male Sprague-Dawley rats. Rats were implanted subcutaneously with 6 morphine pellets during a 7-day period. The pellets...

...Hemendra N. Bhargava; Nafasat H. Rahmani; Vincent M. Villar; Karl Larsen Effects of naltrexone administered intravenously on the pharmacological actions and kinetics of morphine in serum following intravenous administration of morphine were determined in male Sprague-Dawley rats. A 10 mg/kg dose...

...Maria Turon; Wieslawa A. Fogel; Jan Bugajski The effect of inhibition of brain histamine synthesis by α-fluoromethylhistidine (α-FMH) on the pituitary adrenocortical activity stimulated by D-Ala-·D-Leu-enkephalinamide (DADL) and morphine was investigated indirectly through corticosterone secretion...