... approved by the FDA as an emergency clinical therapy. But it may not be effective alone to control the disease as it can only control the viral replication in the host. Summary: This article summarizes the possible therapeutic potential and benefits of using montelukast, a cysteinyl leukotriene 1 (CysLT 1...

...Gioacchino Calapai; Marco Casciaro; Marco Miroddi; Fabrizio Calapai; Michele Navarra; Sebastiano Gangemi Background: Montelukast, a leucotriene receptor antagonist, binds the cysteinyl leucotriene type 1 receptor. Montelukast is commonly prescribed to asthma patients as add-on therapy to inhaled...

... actions of histamine and leukotriene D 4 (LTD 4 ), a cysteinyl leukotriene, on porcine nasal arteries and veins. We also studied combined blocks of histamine and cysteinyl leukotrienes using loratadine and montelukast in an in vivo model of allergy-mediated nasal inflammation. Methods: For the evaluation...

... and mice. However, whether the neuroprotective effect of pranlukast is its special action or a common action of CysLT 1 receptor antagonists remains to be clarified. This study was performed to determine whether montelukast, another CysLT 1 receptor antagonist, has the neuroprotective effect on focal...