... inhibitors (SSRIs). The marble burying test in mice is commonly used to model OCD and has been shown to be sensitive to SSRIs, which decrease burying behavior. The activity of SSRIs in this model is mediated through activation of 5-hydroxytryptamine (5-HT) 1A receptors, but the respective implication of pre...

... to parasympathetic nerve stimulation induced by electrical field stimulation (EFS) in mice. In isolated mouse UBSM, EFS (1-16 Hz) produced tetrodotoxin-sensitive, frequency-dependent contractions. The contractile responses to EFS were largely attenuated by atropine (10 -6 mol/l). UBSM contractility that occurred...

..., but the uncontrolled development of sickness behavior may trigger negative feelings or chronic depressive events. This study aims at investigating the potential effect of pifithrin-μ, an inhibitor of heat shock protein 70 substrate binding activity, on lipopolysaccharide (LPS)-induced sickness response. C57BL/6J mice...

... atypical agents. In this study, we investigated the effect of aripiprazole on seizure of mice in sub-chronic treatments. We also examined the interaction of nitric oxide (NO) with aripiprazole in seizure experiments. Mice received aripiprazole for 6 days and then on the 7th day aripiprazole was injected 60...

...Cristiano R. Jesse; Cristina W. Nogueira This study was designed to evaluate the role of spinal glutamatergic receptors and neurokinin 1-mediated pathway in the antinociception elicited by tramadol in mice. Tramadol (1–50 mg/kg), given intraperitoneally (i.p.), produced significant inhibition...

... detection following Phortress administration to mice (10 mg/kg, intravenously on days 1 and 8). Phortress (20 mg/kg, on days 1 and 8) was administered to CYP1A1/βGAL reporter mice; tissues were examined macro- and microscopically. Toxicological and pharmacodynamic endpoints were examined in organs...

... Swiss Webster mice and male Sprague-Dawley rats. In mice, high activity of NOS was found in cerebellum, hypothalamus and midbrain; intermediate activity in pons-medulla, hippocampus, amygdala, corpus striatum and cortex; and low activity in the spinal cord. In rat, highest activity of NOS was observed...

...N. Saha; H. Datta; P.L. Sharma The effects of morphine on memory have been shown to be dependent on the strain of animal used and on the experimental parameters. Memory was assessed in a passive avoidance task using Swiss albino (ICRC) mice. Morphine at doses of 1 3 and 10 mg kg –1 was administered...

...L. Pénzes; H.-D. Fischer; Ch. Wustmann; E. Rudolph; J. Oehler; M. Jähkel; A. Rostock; Ch. Siegemund Male CBA/Ca inbred mice were treated with a dose of 8 μg 2-mercapto-ethanol per animal per day in the drinking water from the age of 5 months onwards up to the age of 24 months. Dopamine release...

... response to sheep red blood cell immunization were investigated in mice. Animals treated with (–)-7-OH-delta-6-THC-DMH (0.01, 0.05, 0.1 and 0.5 mg/kg) exhibited a dose-dependent suppression of both phases of the primary humoral immune response in the hemolytic plaque assay, the hemagglutination titer...

...Soter Dai; Clive W. Ogle; Chi H. Cho Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased...

...S.K. Tilak; A.M. Zimmerman Effects of Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) (1, 3 or 5 μ M for 2 h) on macromolecular synthesis were investigated in homogeneous populations of pachytene spermatocytes and round spermatids obtained from CD-1 mice. Incorporation of 3H...

...) immunization was investigated. Mice treated with THC (10 and 15 mg/kg) during the primary immunization period exhibited a suppression of the primary humoral immune response. Mice treated with THC during the secondary immunization period showed no measurable suppression of the secondary humoral immune response...

... no impairment of the in vitro primary-like immune response. 24 03 1982 18 06 1982 4 6 2008 Pharmacology 26: 12-19 (1983) ©1983 S. KargerAG. Basel 0031-7012/83/0261-0012S2.75/0 Effects of A9-Tetrahydrocannabinol, Cannabinol and Cannabidiol on the Immune System in Mice II. In vitro...

...Craig Schnell; Haig P. Bozigian; Marc H. Davies; Alex Merrick; Kyung S. Park; D.A. McMillan Experiments were conducted to examine the effects of changes in lighting schedules and food consumption on circadian rhythms in acetaminophen lethality and hepatic glutathione levels in male mice. Under...

...Ingmar Lundquist Insulin secretion and blood glucose homeostasis were studied in mice following administration of cholinergic agonists, antagonists and other possible modifiers of cholinergic insulin secretory mechanisms. It was observed that administration to mice of the cholinergic agonists...

...Robert Burns; Susan S. Beland The LD 50 was determined for 5-fiuorouracil (FU) in mice at 11.00 and 23.00 h during one 24-hour period. These times were chosen because in mice kept on a light-dark cycle, with lights on from 06.00 to 18.00 h, the natural circadian rhythm in DNA synthetic activity...

...A.B. Kostellow; D. Ziegler; J. Kunar; G.I. Fujimoto; G.A. Morrill Virgin A/J female mice were intubated daily for 8 days (short term) or 70 days (long term) with 0, 1, 5, or 25 mg/kg Δ 9 -tetrahydrocannabinol (Δ 9 -THC) or 0, 3, 15, or 75 mg/kg crude marihuana extract (CME) in a sesame...

...Bruce H. Kroening; Michael Weintraub The influence of age on tissue distribution of digoxin in mice and guinea pigs and uptake by mouse heart slices was investigated. 4 h after a single dose of 3 H-digoxin, tissue:plasma ratios were significantly greater in very young animals and declined...

..., 96 h after intraperitoneal administration of QdB to mice and rats, respectively. Plasma levels of 14 C were low and decreased with time, whereas tissue concentrations were high and remained elevated. Differences in tissue concentrations observed in the rat 96 h following intravenous...