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1-20 of 32
Keywords: Mice
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Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2021) 106 (1-2): 114–118.
Published Online: 18 September 2020
... inhibitors (SSRIs). The marble burying test in mice is commonly used to model OCD and has been shown to be sensitive to SSRIs, which decrease burying behavior. The activity of SSRIs in this model is mediated through activation of 5-hydroxytryptamine (5-HT) 1A receptors, but the respective implication of pre...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2017) 99 (3-4): 106–113.
Published Online: 01 November 2016
... to parasympathetic nerve stimulation induced by electrical field stimulation (EFS) in mice. In isolated mouse UBSM, EFS (1-16 Hz) produced tetrodotoxin-sensitive, frequency-dependent contractions. The contractile responses to EFS were largely attenuated by atropine (10 -6 mol/l). UBSM contractility that occurred...
Journal Articles
Journal:
Pharmacology
Pharmacology (2016) 97 (5-6): 245–250.
Published Online: 17 February 2016
..., but the uncontrolled development of sickness behavior may trigger negative feelings or chronic depressive events. This study aims at investigating the potential effect of pifithrin-μ, an inhibitor of heat shock protein 70 substrate binding activity, on lipopolysaccharide (LPS)-induced sickness response. C57BL/6J mice...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2015) 95 (5-6): 264–270.
Published Online: 22 May 2015
... atypical agents. In this study, we investigated the effect of aripiprazole on seizure of mice in sub-chronic treatments. We also examined the interaction of nitric oxide (NO) with aripiprazole in seizure experiments. Mice received aripiprazole for 6 days and then on the 7th day aripiprazole was injected 60...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2010) 85 (1): 36–40.
Published Online: 16 December 2009
...Cristiano R. Jesse; Cristina W. Nogueira This study was designed to evaluate the role of spinal glutamatergic receptors and neurokinin 1-mediated pathway in the antinociception elicited by tramadol in mice. Tramadol (1–50 mg/kg), given intraperitoneally (i.p.), produced significant inhibition...
Journal Articles
Subject Area:
Pharmacology
T.D. Bradshaw, J.E. Wren, M. Bruce, D.A. Barrett, C.-O. Leong, M. Gaskell, E.K. Wright, P.B. Farmer, C.J. Henderson, R. Wolf, M.F.G. Stevens
Journal:
Pharmacology
Pharmacology (2009) 83 (2): 99–109.
Published Online: 17 December 2008
... detection following Phortress administration to mice (10 mg/kg, intravenously on days 1 and 8). Phortress (20 mg/kg, on days 1 and 8) was administered to CYP1A1/βGAL reporter mice; tissues were examined macro- and microscopically. Toxicological and pharmacodynamic endpoints were examined in organs...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1995) 50 (3): 168–174.
Published Online: 10 June 2008
... Swiss Webster mice and male Sprague-Dawley rats. In mice, high activity of NOS was found in cerebellum, hypothalamus and midbrain; intermediate activity in pons-medulla, hippocampus, amygdala, corpus striatum and cortex; and low activity in the spinal cord. In rat, highest activity of NOS was observed...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1991) 42 (1): 10–14.
Published Online: 06 June 2008
...N. Saha; H. Datta; P.L. Sharma The effects of morphine on memory have been shown to be dependent on the strain of animal used and on the experimental parameters. Memory was assessed in a passive avoidance task using Swiss albino (ICRC) mice. Morphine at doses of 1 3 and 10 mg kg –1 was administered...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1990) 40 (6): 343–348.
Published Online: 05 June 2008
...L. Pénzes; H.-D. Fischer; Ch. Wustmann; E. Rudolph; J. Oehler; M. Jähkel; A. Rostock; Ch. Siegemund Male CBA/Ca inbred mice were treated with a dose of 8 μg 2-mercapto-ethanol per animal per day in the drinking water from the age of 5 months onwards up to the age of 24 months. Dopamine release...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1989) 39 (6): 337–349.
Published Online: 05 June 2008
... response to sheep red blood cell immunization were investigated in mice. Animals treated with (–)-7-OH-delta-6-THC-DMH (0.01, 0.05, 0.1 and 0.5 mg/kg) exhibited a dose-dependent suppression of both phases of the primary humoral immune response in the hemolytic plaque assay, the hemagglutination titer...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1986) 33 (1): 58–60.
Published Online: 04 June 2008
...Soter Dai; Clive W. Ogle; Chi H. Cho Using the method of staining mucus with Alcian blue and destaining it with magnesium chloride, it was found that intragastric administration of carbenoxolone in mice did not significantly affect duodenal mucus synthesis at doses which remarkably increased...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1983) 26 (1): 1–11.
Published Online: 04 June 2008
...) immunization was investigated. Mice treated with THC (10 and 15 mg/kg) during the primary immunization period exhibited a suppression of the primary humoral immune response. Mice treated with THC during the secondary immunization period showed no measurable suppression of the secondary humoral immune response...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1983) 26 (1): 12–19.
Published Online: 04 June 2008
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cannabidiol Cannabinoids Cannabinol Immune response Lymphocyte Mice Δ 9 -Tetrahydrocannabinol Pharmacology 26...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1984) 28 (5): 296–300.
Published Online: 04 June 2008
...Robert Burns; Susan S. Beland The LD 50 was determined for 5-fiuorouracil (FU) in mice at 11.00 and 23.00 h during one 24-hour period. These times were chosen because in mice kept on a light-dark cycle, with lights on from 06.00 to 18.00 h, the natural circadian rhythm in DNA synthetic activity...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1984) 29 (3): 149–157.
Published Online: 04 June 2008
...Craig Schnell; Haig P. Bozigian; Marc H. Davies; Alex Merrick; Kyung S. Park; D.A. McMillan Experiments were conducted to examine the effects of changes in lighting schedules and food consumption on circadian rhythms in acetaminophen lethality and hepatic glutathione levels in male mice. Under...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1982) 25 (6): 338–347.
Published Online: 04 June 2008
...Ingmar Lundquist Insulin secretion and blood glucose homeostasis were studied in mice following administration of cholinergic agonists, antagonists and other possible modifiers of cholinergic insulin secretory mechanisms. It was observed that administration to mice of the cholinergic agonists...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1984) 29 (6): 343–350.
Published Online: 04 June 2008
...S.K. Tilak; A.M. Zimmerman Effects of Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) (1, 3 or 5 μ M for 2 h) on macromolecular synthesis were investigated in homogeneous populations of pachytene spermatocytes and round spermatids obtained from CD-1 mice. Incorporation of 3H...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1980) 21 (1): 68–75.
Published Online: 30 May 2008
...A.B. Kostellow; D. Ziegler; J. Kunar; G.I. Fujimoto; G.A. Morrill Virgin A/J female mice were intubated daily for 8 days (short term) or 70 days (long term) with 0, 1, 5, or 25 mg/kg Δ 9 -tetrahydrocannabinol (Δ 9 -THC) or 0, 3, 15, or 75 mg/kg crude marihuana extract (CME) in a sesame...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1980) 20 (1): 21–26.
Published Online: 30 May 2008
...Bruce H. Kroening; Michael Weintraub The influence of age on tissue distribution of digoxin in mice and guinea pigs and uptake by mouse heart slices was investigated. 4 h after a single dose of 3 H-digoxin, tissue:plasma ratios were significantly greater in very young animals and declined...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1978) 16 (3): 131–134.
Published Online: 29 May 2008
...Charles L. Litterst Drug metabolism by hepatic microsomal and soluble fractions was compared in male C57B1/6 mice purchased from three different suppliers. Mice were studied at 9 weeks of age after having been purchased either as weanlings or at 8 weeks of age. Significant differences were found...
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