...Robert Krysiak; Marcin Basiak; Witold Szkróbka; Bogusław Okopień Introduction: Metformin was found to reduce elevated levels of anterior pituitary hormones. Its thyrotropin-lowering effect was more pronounced in individuals receiving myo-inositol. The aim of the present study was to investigate...

...Robert Krysiak; Karolina Kowalcze; Bogusław Okopień Introduction: Metformin reduces elevated levels of FSH and LH. In some studies, gonadotroph secretory function was inhibited by statins. The aim of the present study was to investigate whether statin therapy modulates the impact of metformin...

...Livia Mueller; Michel Moser; Josef Prazak; Daniel G. Fuster; Joerg C. Schefold; Patrick Zuercher Introduction: Metformin-treated patients may experience severe hyperlactatemia or lactic acidosis (LA). LA often requires intensive-care-unit (ICU) treatment, and mortality rates are high. Here, we...

... genetic variants and plasma levels of HbA1c in 100 patients under treatment with metformin. Methods: HbA1c was measured in a clinical chemistry analyzer (Roche), genotyping was performed in an Illumina-GSA array and data were analyzed using PLINK. Association and prediction models were developed using R...

... by direct targeting of gp130. Although LMT-28 and metformin both possess anti-inflammatory activity, the beneficial effect of LMT-28 and metformin combination on a collagen-induced arthritis (CIA) model has not yet been investigated. This study aimed to investigate the anti-inflammatory effect and mechanism...

...Mu-chao Wu; Wei-ran Ye; Yi-jia Zheng; Shan-shan Zhang Metformin (MET) is the first-line drug for treating type 2 diabetes mellitus (T2DM). However, MET increases blood lactate levels in patients with T2DM. Lactate possesses proinflammatory properties and causes insulin resistance (IR). Oxamate (OXA...

... studied patients with type 2 diabetes, treated with metformin, insulin combined with metformin and conventional insulin. IL-1β, IL-6 and IL-10 serum levels were assayed using BD™ Cytometric Bead Array. Multivariate analysis of covariance was performed to exclude the impact of some metabolic...

...Azza M. Baraka; Maha M. Deif Background: The potential utility of 5′-adenosine monophosphate-activated protein kinase (AMPK)-activating agents, such as metformin, in inducing angiogenesis, could be a promising approach to promote healing of gastric ulcers complicated by diabetes mellitus. The aim...

...Chun Wing Yeung; Ho Yin Chung; Bonnie Mei Wah Fong; Nga Wing Tsai; Wai Ming Chan; Tak Shing Siu; Sidney Tam; Sik Hon Tsui Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time...

..., glyburide, or by a biguanide, metformin. PZG’s glucose- and lipid-lowering effects were dose-dependent. These metabolic effects were also investigated after: (a) pyrazinoic acid (PZA), a metabolite of PZG; (b) 3-amino-PZG, an analog of PZG, and (c) 3-amino-PZA, a hydrolytic product of 3-amino-PZG. PZA...

.... Antihyperglycemic drug Antihyperlipidemic drug Diabetes mellitus Hydrochlorothiazide Metformin Plasma glucose Plasma lipids Pyrazinoylguanidine Pharmacology Original Paper Pharmacology 1996;52:135-144 Yousifl. A-Rahim Karl H. Beyer, Jr. ElliotS. Vesell Department of Pharmacology, Pennsylvania State...

...Leif Jansson The aim of the present study was to evaluate if metformin, a biguanide used in the treatment of noninsulin-dependent diabetes, induced any changes in splanchnic circulation. For this purpose, anesthetized rats were injected intraperitoneally with saline alone (1 ml/kg BW) or metformin...